Results 81 to 90 of about 436,571 (380)

IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes

Cells, 2023
Ferroptosis has emerged as a cytotoxic T lymphocyte (CTL)-induced tumor cell death pathway. The regulation of tumor cell sensitivity to ferroptosis is incompletely understood.
Dakota B. Poschel, Mercy Kehinde-Ige, John D. Klement, Dafeng Yang, Alyssa D. Merting, Natasha M. Savage, Huidong Shi, Kebin Liu   +7 more
doaj   +1 more source

A Team Based Variant of CTL

2015 22nd International Symposium on Temporal Representation and Reasoning (TIME), 2015
TIME 2015 conference version, modified title and ...
Arne Meier, Andreas Krebs, Jonni Virtema
openaire   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Immune checkpoint inhibitor-induced isolated adrenocorticotropic hormone deficiency: a systematic review

Frontiers in Endocrinology
BackgroundImmune checkpoint inhibitor-induced isolated adrenocorticotropic hormone deficiency (IAD) is a rare but potentially fatal disease.MethodsWe comprehensively searched the PubMed database and made a systematic review of immune checkpoint inhibitor-
Fen Wang, Xiaoli Shi, Xuefeng Yu, Yan Yang   +3 more
doaj   +1 more source

High CD8+tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma

Frontiers in Immunology, 2023
BackgroundExhaustion of CD8+ tumor-infiltrating lymphocytes (TILs), characterized by the overexpression of immune checkpoints (IC), is a major impediment to anti-tumor immunity.
Qiqi Zhu, Qiqi Zhu, Yiming Yang, Yiming Yang, Xueqin Deng, Ningning Chao, Zihang Chen, Yunxia Ye, Wenyan Zhang, Weiping Liu, Sha Zhao   +10 more
doaj   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Achilles’ Heel of currently approved immune checkpoint inhibitors: immune related adverse events

Frontiers in Immunology
Immunotherapy has revolutionized the cancer treatment landscape by opening up novel avenues for intervention. As the use of immune checkpoint inhibitors (ICIs) has exponentially increased, so have immune-related adverse events (irAEs).
Ting Yan, Lun Yu, Jiwen Zhang, Jiwen Zhang, Yun Chen, Yilan Fu, Jingyi Tang, Dehua Liao   +7 more
doaj   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Lichen planus: A Systematic Review

Journal of Education, Health and Sport
Lichen planus (LP) is a chronic skin, mucous membrane, and nail disease. Lichen planus is a rare skin condition occurring in less than 1% of the general population, affecting both children and adults.
Karolina Garbacz, Maria Maciąg, Małgorzata Pasztelan, Jarosław Pulikowski, Małgorzata Słaboń, Maciej Sobczyk, Aleksandra Muca, Aleksandra Marczak, Julia Krawczuk vel Walczuk, Joanna Baran   +9 more
doaj   +1 more source

Identification and validation of telomerase related lncRNAs signature to predict prognosis and tumor immunotherapy response in bladder cancer

Scientific Reports, 2023
Telomerase allows eukaryotic cells to proliferate indefinitely, an important characteristic of tumor cells. Telomerase-related long no coding RNAs (TERLs) are involved in prognosis and drug sensitivity prediction; however, their association with bladder ...
Xiaoxu Chen, Zheng Qin, Xiao Zhu, Lili Wang, Changying Li, Haitao Wang   +5 more
doaj   +1 more source