Results 111 to 120 of about 22,609,350 (346)

Supplementary Fig S5 from Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

, 2013
Supplementary Fig S5 - PDF file 51K, Figure S5.
Mark J. Smyth (42440), Bertrand Allard (13533994), John Stagg (769243), Sandra Pommey (13612321)   +3 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy

Cellular Physiology and Biochemistry, 2018
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a membrane glycoprotein expressed by activated effector T cells (Teffs) and participates in the repression of T cell proliferation, cell cycle progression and cytokine production.
Yinghao Zhao, Wei Yang, Yuanyuan Huang, Ranji Cui, Xiangyan Li, Bingjin Li   +5 more
doaj   +1 more source

Reciprocal Dosing of Anti-PD-1 and Anti-CTLA-4 Antibodies in a Staged MC38 Tumor Model.

, 2016
Reciprocal Dosing of Anti-PD-1 and Anti-CTLA-4 Antibodies in a Staged MC38 Tumor Model.
Mark J. Selby (3110964), Li-Sheng Lu (3110973), Bing Chen (32669), Jose Valle (3110955), Pina M. Cardarelli (3110967), Dapeng Yao (590961), Kent Thudium (3110958), Alan J. Korman (414640), John J. Engelhardt (3110952), Minhua Han (3110949), Diann Blanset (3110961), Robert J. Johnston (502201), Michael Quigley (3110970), Changyu Wang (115293)   +13 more
core   +1 more source

The price of tumor control [PDF]

, 2013
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
Berking, Carola, Bockmeyer, Clemens L., Voskens, Caroline J., Fluck, Michael, Heinzerling, Lucie M., Schuler, Gerold, Vaubel, Julia, Keller, Ullrich, Goldinger, Simone M., Wilhelm, Tabea, Moos, Roger von, Mohr, Peter, Eigentler, Thomas, Paetzold, Sylvie, Justich, Armin, Hundorfean, Gheorghe, Hauschild, Axel, Mateus, Christine, Klein, Christina, Loquai, Carmen, Schadendorf, Dirk, Göppner, Daniela, Robert, Caroline, Bergmann, Tanja, Gutzmer, Ralf, Hein, Rüdiger, Grabbe, Stephan, Dummer, Reinhard, Kaehler, Katharina C., Trefzer, Uwe, Ulrich, Jens, Weder, Patrik, Schuler-Thurner, Beatrice, Garbe, Claus, Satzger, Imke, Schlaeppi, Marc   +35 more
core   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Correlation Between IFNγ+ and CTLA-4+ Tumor Infiltrating Lymphocytes In Luminal And Non-Luminal Breast Carcinoma

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2019
The role of tumor infiltrating lymphocytes (TIL) in breast carcinoma depends on the molecular subtype, especially the expression of the estrogen receptor.
Irene Lingkan Parengkuan, Sjahjenny Mustokoweni, Nila Kurniasari   +2 more
doaj   +1 more source

CTLA-4 is a second receptor for the B cell activation antigen B7

Journal of Experimental Medicine, 1991
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate
P. Linsley, W. Brady, Mark Urnes, L. Grosmaire, N. Damle, J. Ledbetter   +5 more
semanticscholar   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Supplementary Fig S1 from Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

, 2013
Supplementary Fig S1 - PDF file 103K, Figure S1.
Mark J. Smyth (42440), Bertrand Allard (13533994), John Stagg (769243), Sandra Pommey (13612321)   +3 more
core   +1 more source