Results 131 to 140 of about 22,609,350 (346)

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Nature Medicine, 2020
Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events.
J. Wargo, M. Andrews, Connie P. M. Duong, V. Gopalakrishnan, V. Iebba, Wei-Shen Chen, L. Derosa, B. Routy, Gladys Ferrere, Aurélie Fluckiger, M. Roberti, P. Opolon, Whijae Roh, C. Spencer, Irina Fernandez Curbelo, L. Vence, A. Reuben, Z. Cooper, P. Prieto, M. A. Khan, A. Lazar, M. Tetzlaff, C. Hudgens, P. Gaudreau, L. Nezi, D. Raoult, L. Haydu, H. Tawbi, P. Hwu, W. Hwu, R. Amaria, E. Burton, S. Woodman, A. Diab, S. Patel, I. Glitza, Jianhua Zhang, N. Ajami, J. Petrosino, R. Jenq, M. Davies, J. Gershenwald, Padmanee Sharma, J. Allison, A. Futreal, L. Zitvogel, M. Alou, Satoru Yonekura, Alexandria P. Cogdill, R. Arora, L. Little, C. Gumbs, K. Wani, M. Callahan, Mathew Adamow, M. Postow, C. Ariyan, J. Gardner, J. McQuade, M. Wong, Li Zhao   +60 more
semanticscholar   +1 more source

CTLA-4 blockade increases the induction of LCMV gp33specific CTLs and lysis of target cells

, 2011
Copyright information:Taken from "CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion"http://www.jibtherapies.com/content/5/1/9Journal of Immune Based Therapies and Vaccines 2007;5():9-9 ...
Franca Ronchese (78627), Anders E Pedersen (78626)   +1 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

eLife
Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated disorder characterized by intestinal inflammation and epithelial injury. The underlying causes of IBD are not fully understood, but genetic factors have been implicated in genome-
Lulu Qin, Chongbin Hu, Qiong Zhao, Yong Wang, Dongdong Fan, Aifu Lin, Lixin Xiang, Ye Chen, Jianzhong Shao   +8 more
doaj   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Antitumor Responses of Anti-CTLA-4 and Anti-PD-1 Antibodies in Staged MC38 and CT26 Tumor Models.

, 2016
A-B. Groups of 8–12 C57/BL6 mice were sourced from Taconic and subcutaneously injected with 2×106 MC38 cells. After tumors were measured on day 7, mice were randomized (58 mm3 mean tumor volume per group) and then treated with the designated mAb (200 μg ...
Mark J. Selby (3110964), Li-Sheng Lu (3110973), Bing Chen (32669), Jose Valle (3110955), Pina M. Cardarelli (3110967), Dapeng Yao (590961), Kent Thudium (3110958), Alan J. Korman (414640), John J. Engelhardt (3110952), Minhua Han (3110949), Diann Blanset (3110961), Robert J. Johnston (502201), Michael Quigley (3110970), Changyu Wang (115293)   +13 more
core   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Anti-CTLA-4 nanobody as a promising approach in cancer immunotherapy

Cell Death and Disease
Cancer is one of the most common diseases and causes of death worldwide. Since common treatment approaches do not yield acceptable results in many patients, developing innovative strategies for effective treatment is necessary.
Mehregan Babamohamadi, N. Mohammadi, Elham Faryadi, Maryam Haddadi, Amirhossein Merati, Farbod Ghobadinezhad, Roshanak Amirian, Z. Izadi, J. Hadjati   +8 more
semanticscholar   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source