Results 151 to 160 of about 22,609,350 (346)

The cytoplasmic tail of CTLA-4 is dispensable for Nef-induced CTLA-4 down-regulation.

, 2013
a) Accumulation of CTLA-4 on the cell surface after transfection with CTLA-4 Y201AY218G and CTLA-4ΔCT mutants and lower expression after transfection with CTLA-4 LL181AA. Black solid histograms represent the isotype controls.
Rabih Halwani (287270), Mohamed El-Far (141824), Yoav Peretz (141817), Rafick-Pierre Sékaly (118474), Jean-Pierre Routy (118465), Elias K. Haddad (141833), Gordon J. Freeman (267166), Olivier Schwartz (15284), Catherine Isabelle (287264), Nicolas Chomont (175516), Martin Bourbonnière (287265), Younes Chouikh (287268), Simone Fonseca (287266), Petronela Ancuta (93066), Joaquín Madrenas (163511)   +14 more
core   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

The expression of CTLA-4 in hepatic alveolar echinococcosis patients and blocking CTLA-4 to reverse T cell exhaustion in Echinococcus multilocularis-infected mice

Frontiers in Immunology
Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by the infection of Echinococcus multilocularis (E. multilocularis) larvae. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) produces inhibitory signals and induces T cell exhaustion, thereby ...
Yuxuan Yang, Yuxuan Yang, Tana Wuren, Binjie Wu, Binjie Wu, Shilei Cheng, Shilei Cheng, Haining Fan, Haining Fan   +8 more
doaj   +1 more source

Viewpoint: Therapeutic Implications of CTLA-4 Compartmentalization

American Journal of Transplantation, 2003
Understanding the regulatory events involved in the activation and inactivation of T cells is crucial to develop therapeutic approaches for autoimmune diseases and for organ transplantation. Co-stimulatory signals delivered through the CD28 receptor and inhibitory signals through CTLA-4 are required for the proper modulation of T cell responses and the
Baroja, Miren L., Madrenas, Joaquín
openaire   +4 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome

Therapeutic Advances in Medical Oncology
Background: CTLA-4 impedes the immune system’s antitumor response. There are two Food and Drug Administration-approved anti-CTLA-4 agents – ipilimumab and tremelimumab – both used together with anti-PD-1/PD-L1 agents.
Nithya Krishnamurthy, Daisuke Nishizaki, Scott M. Lippman, Hirotaka Miyashita, Mary K. Nesline, Sarabjot Pabla, Jeffrey M. Conroy, Paul DePietro, Shumei Kato, Razelle Kurzrock   +9 more
doaj   +1 more source

Radiolabeled Coordination Polymer‐Loaded Microneedles for Synergistic Melanoma Brachytherapy–Immunotherapy via STING Activation and Pyroptosis

Exploration, EarlyView.
We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu, Shijun Xiang, Lu Hao, Jessica C. Hsu, Kaixuan Li, Rongxuan Yan, Ming Zhou, Yongxiang Tang, Ying Peng, Weibo Cai, Cong Peng, Peng Liu, Shuo Hu   +12 more
wiley   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

Science Translational Medicine, 2018
Loss of membrane MHC class I protein expression in most of tumor cells in advanced melanomas predicts primary resistance to anti–CTLA-4, but not anti-PD1, treatment.
Scott J Rodig, Scott J Rodig, D. Gusenleitner, D. Jackson, E. Gjini, A. Giobbie-Hurder, Chelsea Jin, Han Chang, S. Lovitch, C. Horak, J. Weber, J. Weirather, J. Wolchok, M. Postow, M. Postow, A. Pavlick, J. Chesney, F. Hodi   +17 more
semanticscholar   +1 more source

Degradation of CTLA-4 chimeras.

, 2013
A. CHO cells expressing CTLA-4 chimeras were incubated in medium or medium supplemented with cycloheximide (CHX) at 37°C for 3 hours. Cells were fixed, permeabilised and stained for total CTLA-4 with an unlabeled anti-CTLA-4 Ab followed by Alexa488 anti ...
Satdip Kaur (397530), Omar S. Qureshi (397531), David M. Sansom (397532)   +2 more
core   +1 more source