Results 31 to 40 of about 69,132 (251)

Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders

Frontiers in Immunology, 2022
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under
Adriana Margarit-Soler, Àngela Deyà-Martínez, Àngela Deyà-Martínez, Àngela Deyà-Martínez, Juan Torres Canizales, Alexandru Vlagea, Ana García-García, Ana García-García, Ana García-García, Júlia Marsal, Maria Trabazo Del Castillo, Sílvia Planas, Sílvia Simó, Sílvia Simó, Ana Esteve-Sole, Ana Esteve-Sole, Ana Esteve-Sole, María Suárez-Lledó Grande, María Suárez-Lledó Grande, María Suárez-Lledó Grande, Isabel Badell, Isabel Badell, Montserrat Rovira Tarrats, Montserrat Rovira Tarrats, Montserrat Rovira Tarrats, Francesc Fernández-Avilés, Francesc Fernández-Avilés, Laia Alsina, Laia Alsina, Laia Alsina, Laia Alsina   +30 more
doaj   +1 more source

Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients [PDF]

The Journal of Immunology, 2012
Abstract CTLA-4 is a surface receptor on activated T cells that delivers an inhibitory signal, serving as an immune checkpoint. Treatment with anti–CTLA-4 Abs can induce clinical responses to different malignancies, but the nature of the induced Ag-specific recognition is largely unknown. Using microarrays spotted with >8000 human
Kwek, Serena S, Dao, Vinh, Roy, Ritu, Hou, Yafei, Alajajian, David, Simko, Jeffrey P, Small, Eric J, Fong, Lawrence   +7 more
openaire   +4 more sources

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.

PLoS ONE, 2015
The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice.
Louisa E Jeffery, Omar S Qureshi, David Gardner, Tie Z Hou, Zoe Briggs, Blagoje Soskic, Jennifer Baker, Karim Raza, David M Sansom   +8 more
doaj   +1 more source

Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Sipuleucel-T is a US Food and Drug Administration-approved autologous cellular immunotherapy that improves survival in patients with metastatic castration-resistant prostate cancer (mCRPC).
Padmanee Sharma, Sumit Subudhi, James P Allison, Rahul Aggarwal, Eric J Small, Terence W Friedlander, Brandon Chen, Jaqueline Marquez, Kate Allaire, Alexander Cheung, Sharon Ng, Christopher Nguyen, Matthew Spitzer   +12 more
doaj   +1 more source

64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues. [PDF]

PLoS ONE, 2014
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) targeted therapy by anti-CTLA-4 monoclonal antibody (mAb) is highly effective in cancer patients.
Kei Higashikawa, Katsuharu Yagi, Keiko Watanabe, Shinichiro Kamino, Masashi Ueda, Makoto Hiromura, Shuichi Enomoto   +6 more
doaj   +1 more source

The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection

Viruses, 2023
Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon.
Ása Didriksen Apol, Anni Assing Winckelmann, Rasmus Bülow Duus, Jens Bukh, Nina Weis   +4 more
doaj   +1 more source

Differential Serum IL-37 Levels and Monomorphic CTLA-4 rs5742909 Polymorphism in Type 1 and Type 2 Diabetes Mellitus: An Iraqi Cohort Study

مجلة الكوفة الطبية
Background: Diabetes mellitus (DM) is linked to intricate inflammatory and autoimmune mechanisms. Interleukin-37 (IL-37) functions as a significant anti-inflammatory cytokine, while CTLA-4 serves as an essential immune regulator.
Nora Abdel Wahab Hamza, Ghasoun Mohammed Ali Al Attiyah   +1 more
doaj   +1 more source

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Arthritis Research & Therapy, 2020
Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation.
Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu   +7 more
doaj   +1 more source

CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4 (CTLA-4) GENE POLYMORPHISMS IN BRONCHIAL ASTHMA. [PDF]

International Journal of Advanced Research, 2016
El asma es un trastorno poligénico y multifactorial, estos factores son tanto genéticos como ambientales. El gen CTLA-4 se encuentra en el cromosoma 2q33, un inhibidor clave de la activación de las células T, se expresa solo en las células T auxiliares activadas y desempeña un papel regulador negativo en la respuesta de las células T. Los polimorfismos
SouadMohamed Aboazma, AymanZ. Elsamanoudy, Naglaa Mokhtar, Ahmed Mohsen, AsemA. Hewidy   +4 more
openaire   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source