Results 11 to 20 of about 69,132 (251)
The Iraqi Journal of Medical Sciences, 2020 Background: Chronic hepatitis B (CHB) infection is associated with the depletion of T cells, resulting in weak or absent virus specific T cells reactivity, which is described as ‘exhaustion’.
Yasmin S. Mahdi, Haidar S. Kadhim
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Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. [PDF]
PLoS ONE, 2018 CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells.
Randi B Gombos +26 more
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OncoImmunology, 2021 The monoclonal antibody against CTLA-4, Ipilimumab, is a first-in-class immune-checkpoint inhibitor approved for treatment of advanced melanoma in adults but not extensively studied in children. In light of the fact that the immune response early in life
Aditya Arra +12 more
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Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach
Frontiers in Applied Mathematics and Statistics, 2022 Anti CTLA-4 therapy is aimed at blocking the Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a key cancer immunity cycle checkpoint. The mechanism of action of CTLA-4 may be described as a dynamic competition for the B7 ligand which, subsequently, interferes ...
Ivan Azarov +7 more
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Identification of CTLA-4-Positive Cells in the Human Tonsil
Cells, 2021 CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) was originally defined as a T-lymphocyte antigen and was used as a target in cancer immunotherapy. Unfortunately, the existence of CTLA-4 in cells other than T-lymphocytes is often overlooked. The goal
Markus Tiemann +3 more
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Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches [PDF]
Biology of Blood and Marrow Transplantation, 2017 Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of
David Gallardo +17 more
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CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen [PDF]
The Journal of Immunology, 2001 Abstract p53 is an attractive target for cancer immunotherapy because it is overexpressed in a high proportion of many different types of tumors. However, it is also expressed in normal tissues and acts as a toleragen in vivo. Previously, detailed examination of the repertoire specific for the murine p53261–269 epitope in conventional ...
J, Hernández, A, Ko, L A, Sherman
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CTLA-4 is a second receptor for the B cell activation antigen B7. [PDF]
The Journal of experimental medicine, 1991 Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate interleukin 2 production and T cell proliferation.
P S, Linsley +5 more
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Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo [PDF]
The Journal of Immunology, 2006 Abstract The role of CTLA-4 in tolerance is primarily inferred from knockout and blocking studies. Anti-CD45RB mediates allograft tolerance in mice by inducing CTLA-4 expression on CD4 cells, providing a novel opportunity to determine how therapeutic enhancement of CTLA-4 promotes tolerance.
Paolo R O, Salvalaggio +6 more
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Immune Network, 2002 Background: CTLA-4 (Cytotoxic T Lymphocyte associated Antigen 4, CD152) has been known as a homologue of CD28, an accessory molecule providing a key costimulatory signal for successful antigen-driven activations of T lymphocyte. Most of biochemical and cell biological characteristics of the CD152 protein remain unknown while those of CD28 have been ...
Dae Cheol Rhim, Yong Hoon Chung
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