Results 21 to 30 of about 69,132 (251)
Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen [PDF]
The Journal of Experimental Medicine, 2004 Adoptive transfer of ovalbumin (OVA)-specific T cells from the DO.11 TCR transgenic mouse on a Rag−/− background into mice expressing OVA in pancreatic islet cells induces acute insulitis and diabetes only if endogenous lymphocytes, including regulatory T cells, are removed.
Eggena, Mark P. +5 more
openaire +2 more sources
mAbs, 2023 Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success.
Jiawei Guan +16 more
doaj +1 more source
CTLA-4 Signaling Regulates the Intensity of Hypersensitivity Responses to Food Antigens, but is Not Decisive in the Induction of Sensitization [PDF]
The Journal of Immunology, 2005 Abstract Although food allergy has emerged as a major health problem, the mechanisms that are decisive in the development of sensitization to dietary Ag remain largely unknown. CTLA-4 signaling negatively regulates immune activation, and may play a crucial role in preventing induction and/or progression of sensitization to food Ag.
van Wijk, Femke +7 more
openaire +4 more sources
Antitumor immunity of DNA vaccine based on CTLA-4 fused with HER2 against colon carcinoma
European Journal of Inflammation, 2018 Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) negatively regulates the T cell activation and competes with CD28 in binding with B7.1/B7.2 molecules.
Shumin Huang, Xinxin Yu
doaj +1 more source
Molecules that inhibit T-cell functions: cytochemical localization and shuttling
European Journal of Histochemistry, 2009 Adaptive immune responses to antigens are mediated by specific receptors expressed on B cells (BCR’s) and T cells (TCR’s). Effector cells and memory cells are produced following a proliferative wave that accounts for clonal expansion.
G Santoro +7 more
doaj +3 more sources
CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
Open Life Sciences, 2021 The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma ...
Chen Yan +6 more
doaj +1 more source
CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses
Vaccines, 2020 Studies have shown that blockade of CTLA-4 promoted the expansion of germinal center B-cells in viral infection or immunization with model antigens. Few studies have evaluated the immunological consequences of CTLA-4 blockade during immunization against ...
Phoebe E. Lewis +8 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Journal of Experimental & Clinical Cancer Research, 2021 The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different ...
Hao Zhang +8 more
doaj +1 more source
Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes [PDF]
The Journal of Experimental Medicine, 1998 Evidence has been accumulating that shows that insulin-dependent diabetes is subject to immunoregulation. To determine whether cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is involved, we injected anti–CTLA-4 mAb into a TCR transgenic model of diabetes at different stages of disease.
Lühder, Fred +4 more
openaire +2 more sources