CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant Sporothrix spp. Enolase Antigen [PDF]
VaccinesBackground/Objectives: Sporotrichosis is an emerging zoonotic subcutaneous fungal infection with limited therapeutic options, highlighting the need for improved immunomodulatory strategies.
Giovanna Justino Momente +8 more
doaj +2 more sources
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade [PDF]
Cell, 2018 CTLA-4 immune checkpoint blockade is clinically effective in a subset of patients with metastatic melanoma. We identify a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region of chromosome Xq28, that predicts resistance uniquely to blockade of CTLA-4, but not PD-1.
Jedd Wolchok +2 more
exaly +5 more sources
Targeting cytotoxic lymphocyte antigen 4 (CTLA-4) in breast cancer
European Journal of Medical ResearchBreast cancer (BC) has a high mortality rate and is one of the most common malignancies in the world. Initially, BC was considered non-immunogenic, but a paradigm shift occurred with the discovery of tumor-infiltrating lymphocytes (TILs) and regulatory T
Maryam Jama +2 more
doaj +3 more sources
Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) [PDF]
Cancer, 2007 AbstractCancer immunotherapy centers on modulating the host's tumor‐directed immune response. One promising approach involves augmentation of cell‐mediated immunity by interrupting T‐cell pathways responsible for immune down‐regulation or tolerance. The discovery of cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) and its role as a key negative regulator for ...
Omid Hamid
exaly +3 more sources
Progress in Research on Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) and Bladder Cancer [PDF]
Annals of Urologic Oncology, 2019 Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) was first discovered in 1987 and confirmed to be a protein that is mainly expressed on the surface of activated lymphocytes.
Wei-Ming Fang, Chun Chen
doaj +2 more sources
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer [PDF]
Urologic Oncology: Seminars and Original Investigations, 2006 Costimulatory pathway ligands and receptors can deliver either positive or negative signals to help determine the ultimate fate of activated T lymphocytes. Cytotoxic T lymphocyte antigen-4 (CTLA-4) represents one of the most extensively studied receptors in the costimulatory pathway and has recently been shown to function as a potent inhibitor of T ...
James P Allison
exaly +3 more sources
Postgraduate Medicine, 2017 Objectives: The diagnosis of malignant pleural effusion (MPE) remains a clinical challenge. As a negative regulator of T-cell activation, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been associated with many malignant diseases. However, there is limited data about the relationship between CTLA-4 and MPE.
Fuqiang Wen +2 more
exaly +3 more sources
Cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases
Turkish Journal of Hematology, 2010 OBJECTIVE: The cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is expressed on T lymphocytes, and inhibits the T-cell responses. In animal models, it has been shown that complete CTLA-4 deficiency was lethal due to massive infiltration of tissues by
Faruk Aktürk +2 more
doaj +5 more sources
Evaluating CTLA-4 Antibody-Antigen Binding as a Model for Targeted Immunosuppressant Delivery in Hashimoto's Thyroiditis. [PDF]
MicroPubl BiolAutoimmune disorders such as Hashimoto's thyroiditis lack curative treatments, only therapeutic agents that treat symptoms very broadly and dampen the entire immune system, including healthy cells. Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) is an immune checkpoint receptor expressed on T cells, and in Hashimoto's thyroiditis the overexpression of CTLA-4
Tiruvellore V, Koegle M.
europepmc +3 more sources
Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4) [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) is the most important human immune checkpoint that modulates T cells activity and brings about immune-homeostasis.
Nazli Sotoudeh +4 more
doaj +1 more source