Results 111 to 120 of about 3,058 (215)

Effect of ELX-02 on cystine accumulation and CTNS transcription in embryonic fibroblasts derived from the Ctns^Y226X/Y226X mice.

, 2019
A. Half-cystine in MEFs from CtnsY226X/Y226X mice was progressively decreased by ELX-02 (0, 100, 200 and 400 μg/mL). B. Ctns transcript levels (RT-qPCR) in CtnsY226X/Y226X MEFs were increased by ELX-02 (200 μg/mL).
Pedro Huertas (4891903), Emma J. Brasell (8081969), Lee Lee Chu (8081972), Yojiro Yamanaka (7589195), Iris Alroy (8081981), Paul Goodyer (311966), Brian M. Gilfix (8081987), Murielle M. Akpa (8081975), Idit Eshkar-Oren (8081978), Rachel Corsini (8081984)   +9 more
core   +1 more source

Cadenas globales de suministro y activos intangibles en las industrias del automóvil y aeronáutica [PDF]

Ola Financiera, 2019
La relocalización de las corporaciones transnacionales (CTNs) de las actividades de alta generación de valor ya sea en el más alto nivel (diseño, desarrollo, marcas y propiedad intelectual) o en el más bajo (comercialización, mantenimiento y servicios ...
Claude Serfati , Catherine Sauviat
doaj  

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2374-2380, October 2026.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Integrating Conventional and Emerging Approaches in Cardiovascular Risk Assessment and Management

Public Health Challenges, Volume 5, Issue 3, September 2026.
Conventional risk factors (hypertension, dyslipidaemia, diabetes, smoking, obesity and physical inactivity) account for roughly 70% of population‐attributable cardiovascular risk and anchor a proposed three‐tier pathway: universal low‐cost assessment (Tier 1), selective testing such as hsCRP or PRS where it would change management (Tier 2) and resource‐
Sana Rasheed, Azka Mujeeb, Misbah Sarfraz, Abedin Samadi, Ahmed Asad Raza   +4 more
wiley   +1 more source

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis

Frontiers in Immunology
Cystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene that encodes cystinosin, a ubiquitous lysosomal cystine/H+ antiporter.
Marianna Nicoletta Rossi, Marianna Nicoletta Rossi, Valentina Matteo, Francesca Diomedi-Camassei, Ester De Leo, Olivier Devuyst, Mohamed Lamkanfi, Ivan Caiello, Elena Loricchio, Francesco Bellomo, Anna Taranta, Francesco Emma, Fabrizio De Benedetti, Giusi Prencipe   +13 more
doaj   +1 more source

Regional Organisation and Sex‐Related Differences in Trigeminal Nerve DTI Metrics in Healthy Young Adults

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
DTI of 300 healthy young adults shows a marked fractional anisotropy gradient along the trigeminal nerve, peaking at the root entry zone and decreasing towards Meckel's cave. These normative, sex‐stratified metrics help distinguish physiological variability from potential microstructural abnormalities.
Eduardo Rocha Arruda, Hohana G. Konell, Carlos E. Garrido Salmon   +2 more
wiley   +1 more source

CTN Multiple Comparisons Procedures SOP

, 2016
This procedure is intended for the Lead Investigator and Protocol Development Team within the Clinical Trials Network as guidance for the consideration of multiple statistical comparisons within a protocol.  The Statistics Workgroup of the Data Management and Analysis Subcommittee will examine the proposed rationale for addressing multiple comparisons ...
openaire   +1 more source