Results 81 to 90 of about 2,755 (211)

Development and modeling of a solid‐state microdosimeter for proton therapy applications

open access: yes
Precision Radiation Oncology, EarlyView.
Dante Guido Mercado   +7 more
wiley   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo   +2 more
wiley   +1 more source

Clinical Characterization of Skin Findings on the Hands in Proteus Syndrome

open access: yesPediatric Dermatology, EarlyView.
ABSTRACT Background Proteus syndrome is a progressive asymmetric overgrowth disorder caused by mosaic activating variants in AKT1. It most frequently affects the skin, soft tissues, bones, and central nervous system and increases the risk for certain tumors and venous thromboembolism. A hallmark feature is the progressive plantar cerebriform connective
Samantha D. Verling   +4 more
wiley   +1 more source

Effect of ELX-02 on cystine accumulation and CTNS transcription in embryonic fibroblasts derived from the CtnsY226X/Y226X mice.

open access: yes, 2019
A. Half-cystine in MEFs from CtnsY226X/Y226X mice was progressively decreased by ELX-02 (0, 100, 200 and 400 μg/mL). B. Ctns transcript levels (RT-qPCR) in CtnsY226X/Y226X MEFs were increased by ELX-02 (200 μg/mL).
Pedro Huertas (4891903)   +9 more
core   +1 more source

The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis.

open access: yesPLoS ONE, 2019
BACKGROUND:Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidney ...
Emma J Brasell   +9 more
doaj   +1 more source

Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile.

open access: yesPLoS ONE, 2011
BackgroundClostridium difficile is the leading cause of hospital-associated diarrhoea in the US and Europe. Recently the incidence of C. difficile-associated disease has risen dramatically and concomitantly with the emergence of 'hypervirulent' strains ...
Michael S M Brouwer   +4 more
doaj   +1 more source

Flower Feeding and Reproductive Timing in Spix's Night Monkeys (Aotus vociferans): Evidence From Arboreal Camera Traps

open access: yesEcology and Evolution, Volume 16, Issue 7, July 2026.
This article provides new insights into the diet and reproductive biology of the Spix's night monkeys (Aotus vociferans). This evidence was collected using arboreal camera traps in a tropical mountain rainforest in Southern Ecuador, where documented information on this primate is rare.
Claudia Viganò   +7 more
wiley   +1 more source

Evaluation of topical cysteamine therapy in the CTNS−/− knockout mouse using in vivo confocal microscopy [PDF]

open access: yes, 2011
PurposeThe purpose of this study was to assess the ability of quantitative in vivo confocal microscopy (CM) to detect changes in cystine crystal volume in the cystinosisn (Ctns−/−)mouse cornea following topical cysteamine therapy.MethodsFifteen Ctns ...
Nien, Chyong Jy   +3 more
core  

Perspective of the European Cystic Fibrosis Society on Improving Global Cystic Fibrosis Care

open access: yesPediatric Pulmonology, Volume 61, Issue 7, July 2026.
ABSTRACT Introduction Outcomes for people with the inherited disease, cystic fibrosis, have improved greatly over the last few decades, but one result of this is a widening gap between regions with high income and well‐resourced healthcare systems and low/middle income countries.
Jane C. Davies   +7 more
wiley   +1 more source

XAHRM‐Lab First Results and πXRF First View of UFe4Al8 and UFe10Si2

open access: yesX-Ray Spectrometry, Volume 55, Issue 4, Page 597-604, July/August 2026.
ABSTRACT Following the installation of the Laboratory for the Characterization and Speciation of Aerosols (LCEA) in 2008, and the confirmation of High Resolution Energy Dispersive Spectrometry (HiREDS) as a much promising development for X‐ray Emission Spectrometry in general and Particle Induced X‐ray Emission (PIXE) in particular, the installation of
M. A. Reis   +3 more
wiley   +1 more source

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