Results 71 to 80 of about 9,680 (207)

In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update

open access: yesGenomics, Proteomics & Bioinformatics, 2017
Dietary phenolic compounds (PCs) have been receiving interest for their presumed roles in disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In this regard, in vitro metabolomic approaches are suitable for the
Úrsula Catalán   +4 more
doaj   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

open access: yesSmall, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem   +12 more
wiley   +1 more source

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

open access: yesNature Communications, 2023
Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis.
Marine Berquez   +11 more
doaj   +1 more source

Numerically efficient mechanical modeling of reinforced concrete membrane elements with fixed, interlocked cracks

open access: yesStructural Concrete, EarlyView.
Abstract Compression field approaches such as the Cracked Membrane Model with fixed, interlocked cracks (CMM‐F) are efficient tools for the mechanical modeling of reinforced concrete elements, providing the mechanical model σ=fε$$ \boldsymbol{\upsigma} =f\left(\boldsymbol{\upvarepsilon} \right) $$ required for finite element analyses.
Andreas Näsbom   +2 more
wiley   +1 more source

The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

open access: yesGenome Research, 2000
Nephropathic cystinosis is an autosomal recessive disorder caused by the defective transport of cystine out of lysosomes. Recently, the causative gene (CTNS) was identified and presumed to encode an integral membrane protein called cystinosin.
J. Touchman   +9 more
semanticscholar   +1 more source

Psilocybin‐assisted psychotherapy for methamphetamine use disorder: A pilot open‐label safety and feasibility study

open access: yesAddiction, EarlyView.
Abstract Background & Aims There are few effective treatments for methamphetamine use disorder, despite increasing global demand. Here, we assessed the safety and feasibility of outpatient psilocybin‐assisted psychotherapy for methamphetamine use disorder. Design Single arm, open label pilot study.
Elizabeth Knock   +8 more
wiley   +1 more source

Outdated tools, underestimated harm: Modernizing cannabis surveillance in a post‐legalization era

open access: yesAddiction, EarlyView.
Abstract Background Canada's 2018 legalization of non‐medical cannabis was positioned as a public health initiative, intended to shift cannabis use from criminalization to regulation. Since then, cannabis access and consumption have grown significantly but the systems used to monitor cannabis‐related harms have not kept pace.
Anees Bahji
wiley   +1 more source

Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial

open access: yesAddiction, EarlyView.
Abstract Background and aims Individuals who engage in illicit or nonmedical opioid use may have elevated risk of health and social consequences, including progression to opioid use disorder (OUD). Preventive interventions to reduce this risk are lacking. This trial tested the impact of a primary care‐integrated collaborative care approach for reducing
Jennifer McNeely   +23 more
wiley   +1 more source

Evaluation of new tools for malaria vector control in Cameroon: focus on long lasting insecticidal nets.

open access: yesPLoS ONE, 2013
BackgroundFrom 2006 to 2011, biological activity of insecticides for Indoor Residual Spraying (IRS), conventional treatment of nets (CTNs) or long lasting insecticidal nets (LLINs) was evaluated before their approval in Cameroon.
Josiane Etang   +5 more
doaj   +1 more source

Local Connection of Excitatory Neurons in Rat Motor-Associated Cortical Areas.

open access: yesFrontiers in Neural Circuits, 2013
In spite of recent progress in brain sciences, the local circuit of the cerebral neocortex, including motor areas, still remains elusive. Morphological works on excitatory cortical circuitry from thalamocortical (TC) afferents to corticospinal neurons ...
Takehsi eKaneko
doaj   +1 more source

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