Results 81 to 90 of about 2,225 (187)

The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis.

PLoS ONE, 2019
BACKGROUND:Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidney ...
Emma J Brasell, Lee Lee Chu, Murielle M Akpa, Idit Eshkar-Oren, Iris Alroy, Rachel Corsini, Brian M Gilfix, Yojiro Yamanaka, Pedro Huertas, Paul Goodyer   +9 more
doaj   +1 more source

Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile.

PLoS ONE, 2011
BackgroundClostridium difficile is the leading cause of hospital-associated diarrhoea in the US and Europe. Recently the incidence of C. difficile-associated disease has risen dramatically and concomitantly with the emergence of 'hypervirulent' strains ...
Michael S M Brouwer, Philip J Warburton, Adam P Roberts, Peter Mullany, Elaine Allan   +4 more
doaj   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, EarlyView.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Clinical, biochemical, and molecular spectrum of nephropathic cystinosis: Two novel CTNS mutations

Saudi Journal of Kidney Diseases and Transplantation
Background: Nephropathic cystinosis (NC) is an autosomal recessive disease. Mutations in the CTNS gene encoding the lysosomal membrane cystine transporter cystinosin are identified as the molecular basis of cystinosis.
Zeinab Youssef Abdallah, Rasha Helmy, Walaa S. Nazim, Marwa M. Nabhan, Hanan Abdelaziz, Hala N. Soliman, Ahmed K. Saad, Mona Ibrahim, Amr Sobhi Gouda, Ekram Fateen, Neveen A. Soliman   +10 more
doaj   +1 more source

The association between sleep disturbance and stimulant use: A cross‐lagged examination

Addiction, Volume 121, Issue 8, Page 2116-2126, August 2026.
Abstract Background and aims Sleep disruptions increase the risk of substance misuse. Substance use—especially stimulants—can increase acute and chronic sleep dysfunction. This study aimed to estimate the associations between sleep disturbance and stimulant use over time among participants with stimulant use disorder (StUD).
Viviana E. Horigian, Renae D. Schmidt, Daniel J. Feaster, Rui Duan, Sophia T. Gonzalez, Kathryn Hefner, Dikla Shmueli‐Blumberg, Ashley Vena, Landhing M. Moran, Chloe A. DiCamillo, Shirin Shafazand, Susan Tross, Judith Feinberg   +12 more
wiley   +1 more source

Flower Feeding and Reproductive Timing in Spix's Night Monkeys (Aotus vociferans): Evidence From Arboreal Camera Traps

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This article provides new insights into the diet and reproductive biology of the Spix's night monkeys (Aotus vociferans). This evidence was collected using arboreal camera traps in a tropical mountain rainforest in Southern Ecuador, where documented information on this primate is rare.
Claudia Viganò, Alessandro Mainardi, Pedro Alonso‐Alonso, Malika Gottstein, Víctor Romero, Richar Samaniego, Juan Pablo Uchuari, Katrin Heer   +7 more
wiley   +1 more source

Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration

Biology Open, 2016
Cystine and cysteine are important molecules for pathways such as redox signaling and regulation, and thus identifying cellular deficits upon deletion of the Saccharomyces cerevisiae cystine transporter Ers1p allows for a further understanding of cystine
Jessica A. Simpkins, Kirby E. Rickel, Marianna Madeo, Bethany A. Ahlers, Gabriel B. Carlisle, Heidi J. Nelson, Andrew L. Cardillo, Emily A. Weber, Peter F. Vitiello, David A. Pearce, Seasson P. Vitiello   +10 more
doaj   +1 more source

Perspective of the European Cystic Fibrosis Society on Improving Global Cystic Fibrosis Care

Pediatric Pulmonology, Volume 61, Issue 7, July 2026.
ABSTRACT Introduction Outcomes for people with the inherited disease, cystic fibrosis, have improved greatly over the last few decades, but one result of this is a widening gap between regions with high income and well‐resourced healthcare systems and low/middle income countries.
Jane C. Davies, Egil Bakkeheim, Audrey Chansard, Pavel Drevinek, Christine Dubois, Jess Matthews, Marta Sheremet, Chris Smith   +7 more
wiley   +1 more source

Problems in comparing tobacco regulatory models and excise when only two countries are considered

Addiction, EarlyView.
Simon Chapman, Sam Egger, Becky Freeman
wiley   +1 more source