Results 101 to 110 of about 2,755 (211)

Effect of ELX-02 in CTNS^Y226X/Y226X mice.

, 2019
A. Half-cystine measurements show decrease pathologic accumulation in kidneys of CtnsY226X/Y226X mice treated with 7 injections of ELX-02 (10 mg/kg) over a 3-week period. B. Serum creatinine levels show no toxic effect of repeated ELX-02 treatment (50 mg/
Pedro Huertas (4891903), Emma J. Brasell (8081969), Lee Lee Chu (8081972), Yojiro Yamanaka (7589195), Iris Alroy (8081981), Paul Goodyer (311966), Brian M. Gilfix (8081987), Murielle M. Akpa (8081975), Idit Eshkar-Oren (8081978), Rachel Corsini (8081984)   +9 more
core   +1 more source

Omic Studies on In Vitro Cystinosis Model: siRNA-Mediated CTNS Gene Silencing in HK-2 Cells

Cystinosis is an autosomal recessive disease caused by mutations in the CTNS gene encoding a protein called cystinosine, which is a lysosomal cystine transporter.
Gok-Topak, Elif Damla Go, Topaloglu, Rezan, Baysal, İpek, NEMUTLU, EMİRHAN, EYLEM, CEMİL CAN, ÖZALTIN, FATİH, ULUBAYRAM, KEZBAN, GÜLHAN, BORA, KIR, SEDEF, Gök-Topak, Elif Damla, UÇAR, GÜLBERK, YABANOĞLU ÇİFTÇİ, SAMİYE, Yabanoglu-Ciftci, Samiye   +12 more
core   +1 more source

CTNS mutations in publicly-available human cystinosis cell lines

, 2015
Patient samples play an important role in the study of inherited metabolic disorders. Open-access biorepositories distribute such samples. Unfortunately, not all clinically-characterized samples come with reliable genotype information.
Renee Kinkade, Todd Zankel, Artem Zykovich, Gary Royal   +3 more
core   +1 more source

Cadenas globales de suministro y activos intangibles en las industrias del automóvil y aeronáutica [PDF]

Ola Financiera, 2019
La relocalización de las corporaciones transnacionales (CTNs) de las actividades de alta generación de valor ya sea en el más alto nivel (diseño, desarrollo, marcas y propiedad intelectual) o en el más bajo (comercialización, mantenimiento y servicios ...
Claude Serfati , Catherine Sauviat
doaj  

Mutational Spectrum of the CTNS Gene in Egyptian Patients with Nephropathic Cystinosis

, 2014
Nephropathic cystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene, encoding for cystinosin, a carrier protein transporting cystine out of lysosomes.
Levtchenko, Elena, Soliman, Neveen A., van den Heuvel, Bert, Gamal, Mohamed, Bongaers, Inge, Abdel Hamid, Rehab H., Ibrahim, Mohamed, Marie, Sandrine   +7 more
core   +1 more source

Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis

, 2017
© Springer-Verlag GmbH Germany 2017Melanins form the basis of animal pigmentation. When the sulphurated form of melanin, termed pheomelanin, is synthesized, the sulfhydryl group of cysteine is incorporated to the pigment structure.
Inácio, Ângela, Ângela Inácio, Galván, Ismael, Ólafur K. Nielsen, Ismael Galván, Nielsen, Ólafur K.   +5 more
core   +1 more source

Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis

Frontiers in Immunology
Cystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene that encodes cystinosin, a ubiquitous lysosomal cystine/H+ antiporter.
Marianna Nicoletta Rossi, Marianna Nicoletta Rossi, Valentina Matteo, Francesca Diomedi-Camassei, Ester De Leo, Olivier Devuyst, Mohamed Lamkanfi, Ivan Caiello, Elena Loricchio, Francesco Bellomo, Anna Taranta, Francesco Emma, Fabrizio De Benedetti, Giusi Prencipe   +13 more
doaj   +1 more source

Mutation analysis of the CTNS gene in Iranian patients with infantile nephropathic cystinosis: identification of two novel mutations

, 2017
Nephropathic cystinosis is an inherited lysosomal transport disorder caused by mutations in the CTNS gene that encodes for a lysosomal membrane transporter, cystinosin.
Majid Fardaei, Forough Sadeghipour, Ali Derakhshan, Mitra Basiratnia   +3 more
core   +1 more source

CTN Multiple Comparisons Procedures SOP

, 2016
This procedure is intended for the Lead Investigator and Protocol Development Team within the Clinical Trials Network as guidance for the consideration of multiple statistical comparisons within a protocol.  The Statistics Workgroup of the Data Management and Analysis Subcommittee will examine the proposed rationale for addressing multiple comparisons ...
openaire   +1 more source

Inducible nitric oxide synthase inhibitor 1400W increases Na⁺ ,K⁺ -ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells

, 2018
Nitric oxide (NO) has been shown to play an important role in renal physiology and pathophysiology partly through its influence on various transport systems in the kidney proximal tubule.
Tara McMorrow, Newsholme, Philip, Rodolfo Sumayao, Philip Newsholme, Sumayao, Rodolfo E., Jr., McMorrow, Tara   +5 more
core   +1 more source