Results 71 to 80 of about 3,017 (208)

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang   +4 more
wiley   +1 more source

The National Allergy Centre of Excellence–Addressing Australia's Allergy Burden

open access: yesClinical &Experimental Allergy, EarlyView.
Australia's high allergy burden prompted a national response, leading to the establishment of the National Allergy Centre of Excellence (NACE) in 2022. The NACE has advanced research infrastructure, collaboration, and consumer‐centred care through four pillars, achieving global recognition and accelerating translation into policy, practice, and ...
A. Young   +23 more
wiley   +1 more source

Evaluation of new tools for malaria vector control in Cameroon: focus on long lasting insecticidal nets.

open access: yesPLoS ONE, 2013
BackgroundFrom 2006 to 2011, biological activity of insecticides for Indoor Residual Spraying (IRS), conventional treatment of nets (CTNs) or long lasting insecticidal nets (LLINs) was evaluated before their approval in Cameroon.
Josiane Etang   +5 more
doaj   +1 more source

Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025)

open access: yesJournal of Evidence-Based Medicine, EarlyView.
ABSTRACT With the accelerating population aging, the number of older adult patients with lung cancer continues to increase. These patients often present with multiple chronic diseases and geriatric syndromes, resulting in more complex perioperative management and significantly increased surgical risks.
Daiping Li   +6 more
wiley   +1 more source

amMSC microvesicle transfer of mRNA to CTNS(−/−) mutant fibroblasts.

open access: yes, 2013
(a) RT/PCR amplicon of CTNS (spanning exons 10 to 12) obtained from RNA extracted from amMSC microvesicles. (b) RT/PCR showing absence of CTNS mRNA in GFP-tagged CTNS(−/−) mutant fibroblasts isolated by FACS after 4 days of co-culture with untagged ...
Reyhan El-Kares (311952)   +13 more
core   +1 more source

Local Connection of Excitatory Neurons in Rat Motor-Associated Cortical Areas.

open access: yesFrontiers in Neural Circuits, 2013
In spite of recent progress in brain sciences, the local circuit of the cerebral neocortex, including motor areas, still remains elusive. Morphological works on excitatory cortical circuitry from thalamocortical (TC) afferents to corticospinal neurons ...
Takehsi eKaneko
doaj   +1 more source

Clinical Characterization of Skin Findings on the Hands in Proteus Syndrome

open access: yesPediatric Dermatology, EarlyView.
ABSTRACT Background Proteus syndrome is a progressive asymmetric overgrowth disorder caused by mosaic activating variants in AKT1. It most frequently affects the skin, soft tissues, bones, and central nervous system and increases the risk for certain tumors and venous thromboembolism. A hallmark feature is the progressive plantar cerebriform connective
Samantha D. Verling   +4 more
wiley   +1 more source

Characterization of the CtnsY226X/Y226X mouse model.

open access: yes, 2019
A. Schematic diagram of Ctns transcript showing the Ctns Y226X nonsense mutation in exon 8. B. Half-cystine levels in 9-month old CtnsY226X/Y226X mouse kidneys was elevated compared to wildtype. C. Ctns transcript level (RT-qPCR) in CtnsY226X/Y226X mouse
Pedro Huertas (4891903)   +9 more
core   +1 more source

Development and modeling of a solid‐state microdosimeter for proton therapy applications

open access: yes
Precision Radiation Oncology, EarlyView.
Dante Guido Mercado   +7 more
wiley   +1 more source

The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis.

open access: yesPLoS ONE, 2019
BACKGROUND:Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidney ...
Emma J Brasell   +9 more
doaj   +1 more source

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