Results 101 to 110 of about 3,017 (208)
Cadenas globales de suministro y activos intangibles en las industrias del automóvil y aeronáutica [PDF]
Ola Financiera, 2019 La relocalización de las corporaciones transnacionales (CTNs) de las actividades de alta generación de valor ya sea en el más alto nivel (diseño, desarrollo, marcas y propiedad intelectual) o en el más bajo (comercialización, mantenimiento y servicios ...
Claude Serfati , Catherine Sauviat
doaj
Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis
Frontiers in ImmunologyCystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene that encodes cystinosin, a ubiquitous lysosomal cystine/H+ antiporter.
Marianna Nicoletta Rossi +13 more
doaj +1 more source
CTN Multiple Comparisons Procedures SOP
, 2016 This procedure is intended for the Lead Investigator and Protocol Development Team within the Clinical Trials Network as guidance for the consideration of multiple statistical comparisons within a protocol. The Statistics Workgroup of the Data Management and Analysis Subcommittee will examine the proposed rationale for addressing multiple comparisons ...
openaire +1 more source
Phenotypic variability in cystinosis: Lessons from an atypical case
Nefrología (English Edition)Cystinosis is a rare monogenic autosomal recessive disorder caused by pathogenic variants in the CTNS gene, encoding cystinosin. Loss-of-function of cystinosin leads to intralysosomal cystine accumulation, resulting in cellular dysfunction and ...
Diego Toso +5 more
doaj +1 more source
Effect of ELX-02 in CTNSY226X/Y226X mice.
, 2019 A. Half-cystine measurements show decrease pathologic accumulation in kidneys of CtnsY226X/Y226X mice treated with 7 injections of ELX-02 (10 mg/kg) over a 3-week period. B. Serum creatinine levels show no toxic effect of repeated ELX-02 treatment (50 mg/
Pedro Huertas (4891903) +9 more
core +1 more source
Omic Studies on In Vitro Cystinosis Model: siRNA-Mediated CTNS Gene Silencing in HK-2 Cells
Cystinosis is an autosomal recessive disease caused by mutations in the CTNS gene encoding a protein called cystinosine, which is a lysosomal cystine transporter.
Gok-Topak, Elif Damla Go +12 more
core +1 more source
CTNS mutations in publicly-available human cystinosis cell lines
, 2015 Patient samples play an important role in the study of inherited metabolic disorders. Open-access biorepositories distribute such samples. Unfortunately, not all clinically-characterized samples come with reliable genotype information.
Renee Kinkade +3 more
core +1 more source
, 2019 A. Half-cystine per mg protein after 72-hour exposure to ELX-02 (200 and 400 μg/mL) was 53% of untreated baseline. B. CTNS transcript levels (RT-qPCR) were increased in CTNSW138X/del57kl fibroblasts treated with ELX-02 (200 and 400 μg/mL) for 72 h ...
Pedro Huertas (4891903) +9 more
core +1 more source
CTNS protein and mRNA levels in human fibroblasts.
, 2019 Wildtype (MCH070) and CTNSW138X/W138X fibroblasts (WG1012) treated with ELX-02. A. Densitometry of immunoblots for CTNS in CTNSW138X/W138X fibroblasts after 48-hour treatment with ELX-02 (400 μg/mL). B.
Pedro Huertas (4891903) +9 more
core +1 more source
YLubell/SEA-CTN: surveillance-poct
, 2018 Accounting for aetiology: can regional surveillance data alongside host biomarker-guided antibiotic therapy improve treatment of febrile illness in remote settings? Authors Chandna A1,2, White LJ1,3, Pongvongsa T4, Mayxay M3,4,5, Newton PN3,4, Day NPJ1,3, Lubell Y1,3* Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand ...
openaire +2 more sources