Results 31 to 40 of about 49,499 (264)

Quantitative pharmacodynamics functional evaluation of Chinese medicine Qizhu formula in mice with dynamic near-infrared photoacoustic imaging

Photoacoustics
Background & Aims: Effective anti-fibrotic drugs and new non-invasive evaluation methods for liver fibrosis (LF) are urgently needed. Our study aimed to evaluate the histological effects of the Qizhu (QZ) formula on LF and to explore a non-invasive ...
Qing-Juan Wu, Lan-Yu Chen, Quan-Mei Sun, Ning Wang, Dong Han, Wen-Liang Lv   +5 more
doaj   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Symmetric single-input eccentric tube robot (ETR) for manual use

Current Directions in Biomedical Engineering
Concentric tube robots (CTR) have gained popularity in robotic research due to their potential for smaller instrument sizes, enhanced dexterity and reduced trauma.
Mayer Juliane, Dumancic Marcel, Pott Peter P.   +2 more
doaj   +1 more source

Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR. [PDF]

PLoS ONE, 2017
G protein-coupled receptors (GPCRs) have been found to form heterodimers and modulate or fine-tune the functions of GPCRs. However, the involvement of GPCR heterodimerization and its functional consequences in gonadal tissues, including granulosa cells ...
Shin Matsubara, Akira Shiraishi, Tsubasa Sakai, Toshimi Okuda, Honoo Satake   +4 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Gradient-Based Optimization of Linear Elasticity Mesh Deformation Quality

International Journal of Aerospace Engineering
Mesh deformation based on the linear elasticity method is crucial in aerospace engineering research. However, maintaining mesh quality after significant deformations can be challenging.
Jinxin Zhou, Xiaojun Wu, Bing Chen, Jing Yu, Shenshen Liu, Hongyin Jia   +5 more
doaj   +1 more source

Physics‐Based Compact Modeling of Advanced 3D Nanoscale Vertical NAND Flash Memory

Advanced Electronic Materials, EarlyView.
For advanced 3D NAND flash memory, a unified compact model for SPICE is proposed that spans from the intrinsic unit cell to the full string and captures the electrostatic coupling with adjacent inhibit strings. It can successfully predict read behavior, program/erase dynamics, and interactions between neighboring cells, reflecting array‐level behavior ...
Ilho Myeong, Seonho Shin, Ickhyun Song
wiley   +1 more source

Spatially revealed roles for lncRNAs in Drosophila spermatogenesis, Y chromosome function and evolution

Nature Communications
Unlike coding genes, the number of lncRNA genes in organism genomes is relatively proportional to organism complexity. From plants to humans, the tissues with highest numbers and levels of lncRNA gene expression are the male reproductive organs. To learn
Zhantao Shao, Jack Hu, Allison Jandura, Ronit Wilk, Matthew Jachimowicz, Lingfeng Ma, Chun Hu, Abby Sundquist, Indrani Das, Phillip Samuel-Larbi, Julie A. Brill, Henry M. Krause   +11 more
doaj   +1 more source

3DInkPack—Inkjet Printing of Discrete Sensor Packages for Advanced Rapid Prototyping

Proceedings, 2017
A rapid advanced packaging concept, consisting of inkjet photopolymer printing and Ag nanoparticles printing, was investigated for the construction of a pressure sensor package.
Matic Krivec, Ali Roshanghias, Alfred Binder   +2 more
doaj   +1 more source

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Frontiers in Physiology, 2022
The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodimers
Tayla A. Rees, Tayla A. Rees, Andrew F. Russo, Simon J. O’Carroll, Debbie L. Hay, Debbie L. Hay, Christopher S. Walker, Christopher S. Walker   +7 more
doaj   +1 more source