Results 31 to 40 of about 48,872 (261)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Symmetric single-input eccentric tube robot (ETR) for manual use

Current Directions in Biomedical Engineering
Concentric tube robots (CTR) have gained popularity in robotic research due to their potential for smaller instrument sizes, enhanced dexterity and reduced trauma.
Mayer Juliane, Dumancic Marcel, Pott Peter P.   +2 more
doaj   +1 more source

Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR. [PDF]

PLoS ONE, 2017
G protein-coupled receptors (GPCRs) have been found to form heterodimers and modulate or fine-tune the functions of GPCRs. However, the involvement of GPCR heterodimerization and its functional consequences in gonadal tissues, including granulosa cells ...
Shin Matsubara, Akira Shiraishi, Tsubasa Sakai, Toshimi Okuda, Honoo Satake   +4 more
doaj   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Gradient-Based Optimization of Linear Elasticity Mesh Deformation Quality

International Journal of Aerospace Engineering
Mesh deformation based on the linear elasticity method is crucial in aerospace engineering research. However, maintaining mesh quality after significant deformations can be challenging.
Jinxin Zhou, Xiaojun Wu, Bing Chen, Jing Yu, Shenshen Liu, Hongyin Jia   +5 more
doaj   +1 more source

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Frontiers in Physiology, 2022
The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodimers
Tayla A. Rees, Tayla A. Rees, Andrew F. Russo, Simon J. O’Carroll, Debbie L. Hay, Debbie L. Hay, Christopher S. Walker, Christopher S. Walker   +7 more
doaj   +1 more source

Physics‐Based Compact Modeling of Advanced 3D Nanoscale Vertical NAND Flash Memory

Advanced Electronic Materials, EarlyView.
For advanced 3D NAND flash memory, a unified compact model for SPICE is proposed that spans from the intrinsic unit cell to the full string and captures the electrostatic coupling with adjacent inhibit strings. It can successfully predict read behavior, program/erase dynamics, and interactions between neighboring cells, reflecting array‐level behavior ...
Ilho Myeong, Seonho Shin, Ickhyun Song
wiley   +1 more source

Spatially revealed roles for lncRNAs in Drosophila spermatogenesis, Y chromosome function and evolution

Nature Communications
Unlike coding genes, the number of lncRNA genes in organism genomes is relatively proportional to organism complexity. From plants to humans, the tissues with highest numbers and levels of lncRNA gene expression are the male reproductive organs. To learn
Zhantao Shao, Jack Hu, Allison Jandura, Ronit Wilk, Matthew Jachimowicz, Lingfeng Ma, Chun Hu, Abby Sundquist, Indrani Das, Phillip Samuel-Larbi, Julie A. Brill, Henry M. Krause   +11 more
doaj   +1 more source

3DInkPack—Inkjet Printing of Discrete Sensor Packages for Advanced Rapid Prototyping

Proceedings, 2017
A rapid advanced packaging concept, consisting of inkjet photopolymer printing and Ag nanoparticles printing, was investigated for the construction of a pressure sensor package.
Matic Krivec, Ali Roshanghias, Alfred Binder   +2 more
doaj   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source