Results 131 to 140 of about 71,036 (261)

Molecular determinants underlying enhanced ceftazidime resistance mediated by the β-lactamase CTX-M-55 compared with CTX-M-14

Animal Diseases
Salmonella strains carrying the bla CTX-M-55 gene encoding the β-lactamase CTX-M-55 present markedly greater resistance to ceftazidime (CAZ) than those carrying the bla CTX-M-14 gene encoding CTX-M-14, but the structural basis remains unclear.
Wei Tan, Lihua An, Yifan Zhang, Dongliang Hu, Zhenfang Fu, Shaowen Li, Xianrong Meng   +6 more
doaj   +1 more source

Prevalence and molecular characterization of extended spectrum beta-Lactamases-producing uropathogenic Escherichia coli isolated in Zakho, Iraq

Journal of Microbiology and Infectious Diseases, 2016
Objectives: Uropathogenic Escherichia coli are the most important group of microorganisms responsible for urinary tract infection. A high percentage of uropathogenic E.
Reem F Polse, Samira Y Yousif, Mahde Saleh Assafi   +2 more
doaj   +1 more source

Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital [PDF]

, 2016
Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (
Ardanuy Tisaire, María Carmen, Ayats, Josefina, Cubero, Meritxell, Cuervo Requena, Guillermo, Domínguez Luzón, Ma. Ángeles (María Ángeles), Gallego, Lucía, Liñares Louzao, Josefina, Martí Martí, Sara, Peña Miralles, Carmen, Pujol Rojo, Miquel, Sevillano, Elena, Tubau, Fe   +11 more
core   +1 more source

Performance of the BioFire FilmArray Pneumonia Panel Plus Compared to Standard Microbiology in Lung Transplant Donor and Recipient Samples: A Prospective Cohort Study

Transplant Infectious Disease, EarlyView.
A prospective study demonstrating that the BioFire Pneumonia Panel Plus shows substantial concordance with culture in donor samples and moderate concordance in recipient samples, supporting its potential role in guiding perioperative antibiotic prophylaxis in lung transplantation.
Andrea Lombardi, Giulia Renisi, Lorenzo Rosso, Letizia Morlacchi, Jacopo Fumagalli, Lisa Cariani, Ilaria Righi, Valeria Rossetti, Arianna Liparoti, Cecilia Azzarà, Davide Mangioni, Laura Alagna, Paola Saltini, Maria Francesca Liporace, Chiara Abbruzzese, Annapaola Callegaro, Francesco Blasi, Giacomo Grasselli, Mario Nosotti, Alessandra Bandera   +19 more
wiley   +1 more source

CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA

Emerging Infectious Diseases, 2013
CTX-M extended-spectrum β-lactamase (ESBL)–producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K.
Guiqing Wang, Tiangui Huang, Pavan Kumar Makam Surendraiah, Kemeng Wang, Rashida Komal, Jian Zhuge, Chian-Ru Chern, Alexander A. Kryszuk, Cassidy King, Gary P. Wormser   +9 more
doaj   +1 more source

Active-site protonation states in an Acyl-Enzyme intermediate of a Class A β-Lactamase with a Monobactam Substrate [PDF]

, 2016
The monobactam antibiotic aztreonam is used to treat cystic fibrosis patients with chronic pulmonary infections colonized by Pseudomonas aeruginosa strains expressing CTX-M extended-spectrum β-lactamases.
Coates, L., Cooper, Jonathan B., Ginell, S.L., Langan, P.S., Parks, J.M., Vandavasi, V.G., Weiss, K.L.   +6 more
core   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar, William P. D. Hendricks, David Rainford, William Selleck, Natalia Briones, Christopher Coggins, Natalie Quan, Victoria Zismann, Gwendolen Lorch, Aleksandar Sekulic, Jeffrey M. Trent   +10 more
wiley   +1 more source

Characterization of CTX-M ESBLs in Enterobacter cloacae, Escherichia coli and Klebsiella pneumoniae clinical isolates from Cairo, Egypt

BMC Infectious Diseases, 2009
Background A high rate of resistance to 3rd generation cephalosporins among Enterobacteriaceae isolates from Egypt has been previously reported. This study aims to characterize the resistance mechanism (s) to extended spectrum cephalosporins among ...
Khalaf Noha G, Eletreby Mona M, Hanson Nancy D   +2 more
doaj   +1 more source

Moderate‐Temperature Hydrothermal Treatment Removes Detectable DNA and Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value

Water and Environment Journal, EarlyView.
This graphical abstract shows the overall study design where dewatered wastewater sludge samples were collected and subjected to a range of HT temperatures. Measurement of nucleic acid concentration and antibiotic resistance gene profiles across temperatures showed that HT at moderate temperatures offers sustainable, scalable sludge sanitation and ARG ...
R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge   +3 more
wiley   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source