Results 151 to 160 of about 71,036 (261)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Horizontal transfer of antibiotic resistance genes on abiotic touch surfaces: implications for public health

, 2012
Horizontal gene transfer (HGT) is largely responsible for increasing incidence of antibiotic-resistant infections worldwide. Whilst studies have focussed on HGT in vivo, this work investigates whether the ability of pathogens to persist in the ...
Bonnin, Bonomo, Boyce, Bush, Cohen Stuart, Espírito Santo, Goren, Guet-Revillet, Hong, Jacoby, Keevil, Kramer, Kruse, Kumarasamy, McGann, Mehtar, Nordmann, Nordmann, Noyce, Noyce, Noyce, Overdevest, O’Keefe, Potron, Schmidt, Schmidt, Tuon, Walsh, Warnes, Warnes, Warnes, Weaver, Weaver, Wilks, Wilks, Woodford, Woodford, World Health Organization, Yong   +38 more
core   +1 more source

Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1176-1183, May 2026.
Objective Transition from long‐term denosumab (Dmab) to parathyroid hormone‐analogs or romosozumab (Romo) might expose patients to the risk of the so‐called rebound phenomenon. Adding Romo to Dmab might represent an option in patients experiencing a fracture while on Dmab.
Giovanni Adami, Francesco Pollastri, Angelo Fassio, Filippo Montanari, Anna Piccinelli, Camilla Benini, Emma Pasetto, Carmen Dartizio, Davide Gatti, Maurizio Rossini, Ombretta Viapiana   +10 more
wiley   +1 more source

Lymph node dissection during cystectomy for non‐muscle‐invasive bladder cancer: A systematic review

BJUI Compass, Volume 7, Issue 5, May 2026.
Abstract Background and objective Radical cystectomy (RC) is standard for muscle‐invasive disease (MIBC) and utilised frequently in high‐risk non‐muscle‐invasive bladder cancer (NMIBC). Pelvic lymph node dissection (PLND) is routinely performed during RC for MIBC, demonstrating a survival benefit. However, the oncologic value in NMIBC remains uncertain.
Sean Lim, Lucielle Standish, Harrison Liu, Eldho Paul, Weranja Ranasinghe   +4 more
wiley   +1 more source

BETA-LACTAMASES ESBL AND CTX-M-types

, 2022
Dans les années 1980, la prescription des premières céphalosporines de troisième génération (C3G) en médecine humaine a provoqué la sélection de mutants ou variants de pénicillinases de type TEM ou SHV dénommées : «Bêta-Lactamases à Spectre Elargi/ Etendu » ou BLSE.
Philippon, Alain, Arlet, Guillaume, Iorga, Bogdan   +2 more
openaire   +1 more source

Lymph node surgery after centralization of penile cancer care in Sweden: Extent of use and complications

BJUI Compass, Volume 7, Issue 5, May 2026.
Abstract Objectives The objective of this study is to compare the use of lymph node surgery and complication rates before and after centralization of penile cancer (PeCa) surgery in Sweden. In January 2015, curative surgical care for PeCa was centralized to the Skåne University Hospital in Malmö and the Örebro University Hospital in Örebro.
Åsa Warnolf, Gediminas Baseckas, Dominik Glombik, Oskar Hagberg, Peter Kirrander, Kimia Kohestani, Per Nordlund, Erik Persson, Fredrik Liedberg, Axel Gerdtsson   +9 more
wiley   +1 more source

The Influence of Short‐Term, Severe Low Energy Availability With Varying Protein Content on Substrate Metabolism, High‐Intensity Exercise Performance and Subjective Responses in Young Adults

European Journal of Sport Science, Volume 26, Issue 5, May 2026.
ABSTRACT Low energy availability (LEA) may impact multiple biological processes, but the extent to which it affects exercise performance, and whether macronutrient composition modulates this, remains unclear. This randomised crossover trial investigated the influence of three dietary conditions with varying energy and protein availabilities on ...
Bruna Aguera Reina, Rafaela Silverio Pinto, Gabriel Perri Esteves, João Vitor Mariano, Paul Swinton, Eimear Dolan   +5 more
wiley   +1 more source

pH‐Shift‐Prepared Chlorella pyrenoidosa Protein/Peptide–Calcium Complexes Improve Skeletal Health by Enhanced Intestinal Calcium Utilization in Calcium‐Deficient Rats

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Calcium carbonate supplements often exhibit limited solubility and gastrointestinal precipitation, restricting calcium availability. To address this limitation, an enzyme‐free pH‐shift strategy was applied to prepare Chlorella pyrenoidosa protein (CPP)/peptide–calcium complexes (pH–Ca) and to evaluate their effects on calcium utilization in ...
Yan Yang, Shenwan Wang, Qimeng Zhou, Ye Qi, Bin Zhou, Jing Li, Tao Hou, Bin Li, Hongshan Liang   +8 more
wiley   +1 more source