Results 51 to 60 of about 71,036 (261)

Molecular epidemiology and characterization of an outbreak causing Klebsiella pneumoniae clone carrying chromosomally located bla CTX-M-15 at a German University-Hospital [PDF]

, 2015
Background: Multi-drug resistant Klebsiella pneumoniae strains are a common cause of health care associated infections worldwide. Clonal spread of Klebsiella pneumoniae isolates carrying plasmid mediated CTX-M-15 have been commonly reported. Limited data
Chakraborty, Trinad, Domann, Eugen, Falgenhauer, Linda, Fritzenwanker, Moritz, Hain, Torsten, Imirzalioglu, Can, Mshana, Stephen E.   +6 more
core   +2 more sources

Two novel plasmid-mediated cefotaxime-hydrolyzing β-lactamases (CTX-M-5 and CTX-M-6) fromSalmonella typhimurium [PDF]

FEMS Microbiology Letters, 1998
Two novel plasmid-mediated beta-lactamases (CTX-M-5 and CTX-M-6) produced by Salmonella typhimurium clinical strains were characterized. The enzymes exhibited a pI of 8.4, hydrolyzed oxyimino-beta-lactams and were susceptible to mechanism-based beta-lactamase inhibitors. The respective bla genes were cloned and sequenced.
Gazouli, M, Tzelepi, E, Markogiannakis, A, Legakis, NJ, Tzouvelekis, LS   +4 more
openaire   +3 more sources

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli [PDF]

, 2017
Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing β ...
Baker, K R, Guardabassi, L, Jana, B, Sigurðardóttir, H H   +3 more
core   +2 more sources

Chromosome-Encoded CTX-M-3 from Kluyvera ascorbata : a Possible Origin of Plasmid-Borne CTX-M-1-Derived Cefotaximases [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT A gene identical to plasmid-borne bla CTX-M-3 is present in the chromosome of one Kluyvera ascorbata strain. It is associated with a structure including an inverted repeat right and an open reading frame 477-like gene probably involved in the mobilization of
Rodríguez, María Margarita, Power, Pablo, Radice, Marcela Alejandra, Vay, Carlos, Famiglietti, Angela María Rosa, Galleni, Moreno, Ayala, Juan A., Gutkind, Gabriel Osvaldo   +7 more
openaire   +4 more sources

Genetic contexts related to the diffusion of plasmid-mediated CTX-M-55 extended-spectrum beta-lactamase isolated from Enterobacteriaceae in China

Annals of Clinical Microbiology and Antimicrobials, 2018
Background CTX-M-55 extended-spectrum beta-lactamases are being rapidly disseminated and transmitted in clinical practices around the world. The genetic contexts of the transferable plasmid-mediated bla CTX-M-55 gene in Enterobacteriaceae were detected ...
Xiaoxin Hu, Jianjun Gou, Xiaobing Guo, Zaiqiu Cao, Yuan Li, Hongjian Jiao, Xiaohong He, Yihui Ren, Fuyun Tian   +8 more
doaj   +1 more source

Functional Characterization of CTX-M-14 and CTX-M-15 β-Lactamases by In Vitro DNA Shuffling [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT This work investigated the molecular events driving the evolution of the CTX-M-type β-lactamases by the use of DNA shuffling of fragments of the bla CTX-M-14 and bla CTX-M-15 genes.
Kathy Hiu Laam, Po, Edward Wai Chi, Chan, Sheng, Chen   +2 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

National survey of colistin resistance among carbapenemase-producing Enterobacteriaceae and outbreak caused by colistin-resistant OXA-48-producing Klebsiella pneumoniae, France, 2014 [PDF]

, 2016
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national ...
Dortet, L, Jayol, A, Nordmann, P, Poirel, L   +3 more
core   +1 more source

Molecular and Kinetic Comparison of the Novel Extended-Spectrum β-Lactamases CTX-M-25 and CTX-M-26 [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT CTX-M-25 is a novel extended-spectrum β-lactamase isolated from a single Canadian Escherichia coli isolate. Susceptibility testing demonstrated that this enzyme confers resistance to both cefotaxime and ceftazidime, but the level of resistance was reduced with the addition of β-lactamase ...
Craig J, Munday, David A, Boyd, Nigel, Brenwald, Mark, Miller, Jennifer M, Andrews, Richard, Wise, Michael R, Mulvey, Peter M, Hawkey   +7 more
openaire   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source