Results 191 to 200 of about 20,694 (254)

Cucurbitacins from Bacopa monnieri☆

Phytochemistry, 2007
Four cucurbitacins, bacobitacin A-D (1-4) as well as, a known cytotoxic, cucurbitacin E (5) together with three known phenylethanoid glycosides, monnieraside I, III and plantioside B were isolated form the aerial part of Bacopa monnieri. Their structures were elucidated on the basis of extensive spectroscopic investigations (1D, 2D NMR and ESI-QTOF-MS ...
Pamita, Bhandari, Neeraj, Kumar, Bikram, Singh, Vijay K, Kaul   +3 more
openaire   +2 more sources

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer.

Journal of Medicinal Chemistry, 2023
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity.
Fan Shang, Q. Lu, Tailiang Lin, Miaoxia Pu, Ruoxuan Xiao, Wanmei Liu, Hao Deng, Hong-Yan Guo, Zhe-Shan Quan, Chunyong Ding, Qing-Kun Shen   +10 more
semanticscholar   +1 more source

Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways.

Journal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE Cucurbitacins are highly oxygenated tetracyclic triterpenoids, that represent the major metabolites reported from C. colocynthis (L.) Schrad..
G. Mohamed, S. Ibrahim, Dina S. El-Agamy, Wael M Elsaed, Alaa Sirwi, Hani Asfour, A. Koshak, Sameh S. Elhady   +7 more
semanticscholar   +1 more source

Antiangiogenic effects of cucurbitacin-I

Archives of Pharmacal Research, 2014
Cucurbitacin-I is a naturally occurring tetracyclic triterpenoid compound with diverse physiological actions that include inducing apoptosis and blocking cell cycle progression of various cancer cells. However, its antiangiogenic activity has not yet been examined.
Hyeon Jin, Kim, Jin-Kyung, Kim
openaire   +2 more sources

Cucurbitacin glycosides from Caput nigri

Phytochemistry, 1995
The chemical structures of cabenosides I-L were investigated. These are four of the 12 cucurbitacin glycosides isolated from 'Cabeça-de-negro', the roots of Caput nigri. By means of chemical analyses the structures of cabenosides I-L were elucidated as 10 alpha-cucurbit-5-ene-3 beta,11 alpha,20S,24 xi,25-pentaol [3, 25-di-O-beta-D-glucopyranoside, and ...
K, Nakano, Y, Kanai, K, Murakami, Y, Takaishi   +3 more
openaire   +2 more sources

Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra-high-performance liquid chromatography-tandem mass spectrometry.

Journal of Separation Science, 2023
Watermelon frost, a traditional Chinese medicine produced using watermelon and Glauber's salt, has been widely used for the therapy of oral and throat disorders.
Guizhou Hu, Wenya Liu, Liyan Li
semanticscholar   +1 more source

Cucurbitacins

Journal of Chemical Ecology, 1985
Four species of diabroticites with different host specificities are shown for the first time to sequester cucurbitacins. While all beetles fed on an artificial diet (no cucurbitacins) were readily consumed by Chinese praying mantids, a significant proportion of adultDiabrotica balteata (72%),D. undecimpunctata howardi (46%), andD.
J E, Ferguson, R L, Metcalf
openaire   +2 more sources

Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis.

Biochemical Pharmacology, 2023
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating diseases; it has a considerably poor prognosis and may become the second most lethal malignancy in the next 10 years.
Dongchao Xu, Ajuan Liu, Qiang Liu, Hongchen Zhang, Mengyao Tian, Ying Bian, Xiao-fen Zhang, Meidan Ying, Hongzhang Shen   +8 more
semanticscholar   +1 more source

Cucurbitacins From Bryonia Verrucosa. Isomerization of 2-Hydroxy-3-Keto-Cucurbitacins

Natural Product Letters, 1999
Abstract Three new cucurbitacins as well as thirteen known ones were isolated from the fruits of Bryonia verrucosa. the new compounds were characterized by chemical and spectral methods. an effective and simple method to isomerize 2-hydroxy-3-keto-cucurbitacins in acid media is described.
Antonio Galindo, Nelson Villegas, Horacio Mansilla   +2 more
openaire   +1 more source

A new cucurbitacin profile forCucurbita andreana: A candidate for cucurbitacin tissue culture

Journal of Chemical Ecology, 1993
In addition to previously reported cucurbitacins B,1, and D,2, cucurbitacin E,3, and I,4, aglycones and their glucosides 2-O-β-glucopyranosyl-cucurbitacin E,5, and 2-O-β-glucopyranosyl-cucurbitacin I,6, were isolated and identified as constituents ofCucurbita andreana on the basis of MS, FD-MS, 1 H NMR and(13)C NMR spectroscopy.
F T, Halaweish, D W, Tallamy
openaire   +2 more sources