Results 201 to 210 of about 20,694 (254)

Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2/HO‐1 pathway

Phytotherapy Research
Osteoarthritis (OA) is a complicated joint disorder characterized by inflammation that causes joint destruction. Cucurbitacin B (CuB) is a naturally occurring triterpenoid compound derived from plants in the Cucurbitaceae family. The aim of this study is
Chao Lou, Yuqin Fang, Y. Mei, Wei Hu, Liaojun Sun, Chen Jin, Hua Chen, Wenhao Zheng   +7 more
semanticscholar   +1 more source

Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies

Phytotherapy Research
The most prevalent and bioactive cucurbitacin is Cucurbitacin B (CuB, C32H46O8), which is a tetracyclic triterpene chiefly present in the Cucurbitaceae family.
Meenal Sahu, Tripti Paliwal, Smita Jain, Kanika Verma, Dipjyoti Chakraborty, Shivangi Jaiswal, Jaya Dwivedi, Swapnil Sharma   +7 more
semanticscholar   +1 more source

Cucurbitacins of Colocynthis vulgaris

Phytochemistry, 1988
Abstract The methanolic extract of the fruits of Colocynthis vulgaris on acidic hydrolysis afforded in addition to cucurbitacin I and J a new cucurbitacin designated cucurbitacin T whose structure was elucidated as (24 S )-16,24-anhydro-25-methoxy-2,16α,20β,24-tetrahydroxy-3,11,22-trioxocucurbita-1,5-diene by spectroscopic methods. The biosynthetic
Chandra B. Gamlath, A.A.Leslie Gunatilaka, Khisal A. Alvi, null Atta-ur-Rahman, Sinnathamby Balasubramaniam   +4 more
openaire   +1 more source

Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway

Phytotherapy Research
Osteosarcoma is a common malignant bone tumour characterised by an aggressive metastatic potential. The tumour microenvironment, particularly the M2‐polarised macrophages, is crucial for tumour progression. Cucurbitacin B (CuB), a triterpenoid derivative,
Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui   +7 more
semanticscholar   +1 more source

Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer.

Journal of Ethnopharmacology, 2021
ETHNOPHARMACOLOGICAL RELEVANCE Cucurbitacin B (CuB), extracted from muskmelon pedicel, is a widely available triterpenoid molecule that exerts influence on various biological activities.
Haoyue Zhang, Bei Zhao, Hui Wei, Hairong Zeng, Dong Sheng, Yang Zhang   +5 more
semanticscholar   +1 more source

Cucurbitacin B targets STAT3 to induce ferroptosis in non-small cell lung cancer.

European Journal of Pharmacology
Cucurbitacin B (CuB) is a compound found in plants like Cucurbitaceae that has shown promise in fighting cancer, particularly in lung cancer. However, the specific impact of CuB on ferroptosis and how it works in lung cancer cells has not been fully ...
Zeyao Zeng, Yingying Hu, Jing Xiang, Jiating Su, Huiting Tan, Tianli Lai, Xinming Chen, Guixuan Fang, Li Li, Lianxiang Luo   +9 more
semanticscholar   +1 more source

Cucurbitacin Contents in Hemsleya dolichocarpa

The American Journal of Chinese Medicine, 1991
Hemsleya dolichocarpa was studied for its cucurbitacin contents during growing period. A colorimetric method was used to determine the total cucurbitacin levels, and a TLC densitometric assay was employed for estimating dihydrocucurbitacin F and its acetate, two active principles in Hemsleya plants. Cucurbitacin contents rise progressively from May to
P Q, Yang, S Y, Liu, Z H, Cao, W J, Chang, C T, Che   +4 more
openaire   +2 more sources

Nano-Selenium and Glutathione Enhance Cucumber Resistance to Botrytis cinerea by Promoting Jasmonic Acid-Mediated Cucurbitacin Biosynthesis.

ACS Nano
Nano-selenium (Nano-Se), as a biological stimulant, promotes plant growth and development, as well as defense against biotic and abiotic stresses. Glutathione (GSH) is a crucial antioxidant and is also involved in the plant defense response to various ...
Y. Jia, Lanqi Chen, Lu Kang, Xiaorui Fu, Shuyang Zheng, Yangliu Wu, Tong Wu, Runze Cai, Xiaoying Wan, Ping Wang, Xuebin Yin, Canping Pan   +11 more
semanticscholar   +1 more source

Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis by modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways.

Current Cancer Drug Targets, 2022
BACKGROUND Cucurbitacin D (CuD) is a natural compound that can be isolated in various plant families, mainly from Ecballium Elaterium (L.) A. Rich. (E. Elaterium).
Muhammed Mehdi Üremiş, Nuray Üremiş, E. Tosun, M. Durhan, Y. Çiğremiş, A. Baysar, Y. Türköz   +6 more
semanticscholar   +1 more source

Cucurbitacins from Acanthosicyos horridus

Phytochemistry, 1986
Abstract Roots of Acanthosicyos horridus have yielded, in addition to known triterpenes, cucurbitacins and sterols, dihydro- epi - iso -cucurbitacin D ( epi - iso cucurbitacin R , tetrahydro- epi - iso -cucurbitacin I or tetrahydro- iso -elatericin B), identified on the basis of spectroscopic and chemical evidence, and thus shown for the first ...
Peter J. Hylands, Mostafa S. Magd
openaire   +1 more source