Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release [PDF]
, 2016 Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release
Aliabadi +58 more
core +1 more source
Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability
Drug Delivery, 2010 This study intended to prepare liver-targeting solid lipid nanoparticles (SLNs) with a hepatoprotective drug, cucurbitacin B (Cuc B), using a galactosylated lipid, N-hexadecyl lactobionamide (N-HLBA). The galactosyl-lipid N-HLBA was prepared via the lactone form intermediates of lactobionic acid and synthesized by anchoring galactose to hexadecylamine ...
Wenyu, Wang +6 more
openaire +2 more sources
Antidiabetic Effects of Momordica Charantia (Karela) in Male Long Evans Rat [PDF]
, 2012 The hypoglycemic effect of Momordica charantia (Karela) has been reported from many laboratories. To our knowledge, the underlying biochemical mechanism of action of this important clinical effect has not been reported. During the course of investigation
Afrin, T. (Tanzila) +5 more
core
Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B
Tumor Biology, 2015 Ovarian cancer is the most deadly gynecological cancer. The first line in treatment is platinum-based drugs. However, most patients suffer from tumor recurrence, characterized by resistance to cisplatin. A plausible approach to address the tumor resistance is to co-administer the chemotherapeutic agents along with natural products to offer a ...
Fardous F, El-Senduny +4 more
openaire +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2026, Issue 1, 2026.
Evidence-Based Complementary and Alternative Medicine
wiley +1 more source
The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]
, 2016 In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S +6 more
core +2 more sources
DI-HIDROCUCURBITACINA B: SEMI-SÍNTESE DE NOVOS DERIVADOS GLICOSILADOS
Química Nova, 2015 In the last ten years, the interest in natural and semi-synthetic cucurbitacin derivatives has increased, primarily due their cytotoxic and anti-tumoral activities.
Vanessa R. Machado +6 more
doaj +1 more source
Anticancer Effect of Cucurbitacin B on Head and Neck Cancer
The FASEB Journal, 2018 Head and neck cancer, which includes epithelial malignancies of various origins of the pharynx, larynx, sinuses, oral cavity and nasal cavity, is the sixth most common type of cancer in the world. The primary treatment modality for head and neck cancer involves surgery and aggressive concomitant chemo and radiotherapies. These treatments are associated
Aravinda Krishna Ganapathy +5 more
openaire +1 more source
PITX2 transcription factor is overexpressed and involved in the tumorigenicity of ovarian cancer [PDF]
, 2009 Free Paper Session - Biomedicine: abstract no ...
Chan, DW, Fung, FKC, Liu, VWS, Ngan, HYS
core +2 more sources
Molecular Mechanisms of Cucurbitacin B-induced Ferroptosis in Human Colorectal Cancer Cells
Shipin gongye ke-jiIn order to investigate the anti-colon cancer activity of cucurbitacin B (CuB) and clarify the key role and molecular mechanism of ferroptosis in the anticancer effect of CuB.
Zhiyuan LIU +3 more
doaj +1 more source