Results 101 to 110 of about 17,883 (244)

Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia

Journal of Pharmacological Sciences, 2019
Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges.
Wenjing Ma, Yuchen Xiang, Rui Yang, Te Zhang, Jiaxin Xu, Yezi Wu, Xuewen Liu, Ke Xiang, Huzi Zhao, Ying Liu, Yuan Si   +10 more
doaj   +1 more source

The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]

, 2016
In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S, Dave, Vivek S., Dhore, Pradip W., Gupta, Deepak, Mack, Connor, Raut, Nishikant, Saoji, Suprit   +6 more
core   +2 more sources

Data from Cucurbitacin B Induces Apoptosis by Inhibition of the <i>JAK/STAT</i> Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

, 2023
Nils H. Thoennissen, Gabriela B. Iwanski, Ngan Doan, Ryoko Okamoto, Patricia Lin, Sam Abbassi, Jueping Song, Dong Yin, Melvin Toh, Wei Dong Xie, Jonathan W. Said, H. Phillip Koeffler   +11 more
openalex   +1 more source

Integrated metabolomic and transcriptomic analyses elucidates the molecular mechanisms underlying cucurbitacin accumulation and bitterness development in Luffa fruits

BMC Plant Biology
The fruits of Luffa in the Cucurbitaceae family are characterized by a bitter taste, which is mainly attributed to cucurbitacin. However, the types of cucurbitacins related to bitterness and the molecular mechanism of cucurbitacin accumulation during ...
Dening Zhu, Yujun Wu, Bingwei Yu, Jiazhu Peng, Lianfang Li   +4 more
doaj   +1 more source

Effective Medicinal Plant in Cancer Treatment, Part 2. [PDF]

, 2017
Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects.
Asadi-Samani, Majid., Behzadifar, Masoud., Kooti, Wesam., Nouri, Bijan., Sadeghi, Fatemeh., Servatyari, Karo., Zare Marzouni, Hadi.   +6 more
core  

Modified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation

Drug Delivery, 2018
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine.
Lan Tang, Lulu Fu, Zhuanfeng Zhu, Yan Yang, Boxuan Sun, Weiguang Shan, Zhenhai Zhang   +6 more
doaj   +1 more source

Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability

Drug Delivery, 2010
This study intended to prepare liver-targeting solid lipid nanoparticles (SLNs) with a hepatoprotective drug, cucurbitacin B (Cuc B), using a galactosylated lipid, N-hexadecyl lactobionamide (N-HLBA). The galactosyl-lipid N-HLBA was prepared via the lactone form intermediates of lactobionic acid and synthesized by anchoring galactose to hexadecylamine ...
Wenyu, Wang, Xiuli, Zhao, Haiyang, Hu, Dawei, Chen, Jianchun, Gu, Yihui, Deng, Jin, Sun   +6 more
openaire   +2 more sources

Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release [PDF]

, 2016
Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release
Aliabadi, Allen, Bansal, Cabral, Cajot, Chan, Chen, Chuma, Danquah, Dwan'Isa, Endrizzi, Forrest, Gadelle, Glavas, Gou, Hillmyer, Huynh, Jones, Kataoka, Kim, Lai, Lavasanifar, Lavasanifar, Letchford, Lin, Liu, Liu, Lu, Lu, Mahmud, Miller, Nagarajan, Nishiyama, Olsen, Patel, Patel, Patel, Pratt, Randolph, Romero-Guido, Rupp, Scarano, Schneiderman, Schneiderman, Schroder, Simon, Thakral, Thambi, VanKrevelen, Winkler, Woodruff, Yan, Yang, Yokoyama, Yoon, Yuan, Zhang, Zhang, Zou   +58 more
core   +1 more source

Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B

Tumor Biology, 2015
Ovarian cancer is the most deadly gynecological cancer. The first line in treatment is platinum-based drugs. However, most patients suffer from tumor recurrence, characterized by resistance to cisplatin. A plausible approach to address the tumor resistance is to co-administer the chemotherapeutic agents along with natural products to offer a ...
Fardous F, El-Senduny, Farid A, Badria, Ahmed M, El-Waseef, Subhash C, Chauhan, Fathi, Halaweish   +4 more
openaire   +2 more sources

Data from Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis

, 2023
Samriddhi Shukla, Sajid Khan, Sudhir Kumar, Sonam Sinha, Mohd Farhan, Himangsu K. Bora, Rakesh Maurya, Syed Musthapa Meeran   +7 more
openalex   +1 more source