Results 171 to 180 of about 13,244,565 (235)
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Antitumor activity and mechanism of cucurbitacin B in A549/DDP cells
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023Cucurbitacin B (CuB) is a class of tetracyclic triterpenoids isolated from Cucurbitaceae with a wide range of anti-inflammatory and anti-tumor activities, mainly used in hepatitis and hepatocellular carcinoma, while there is relatively little research and application of this drug for lung cancer. In this study, CuB was administered on A549/DDP cells to
Xinyuan Yu +7 more
semanticscholar +3 more sources
Journal of Chromatography B, 2017
Cucurbitacin B (CuB) and cucurbitacin E (CuE) are tetracyclic triterpene compounds from Cucurbitaceae, and the main bioactive compounds of cucurbitacins tablets that used to treatment of chronic hepatitis. Pharmacological research has been very comprehensive, and there are few studies on pharmacokinetics, especially about CuE. An Ultra High Performance
Zhibin, Wang +8 more
openaire +4 more sources
Cucurbitacin B (CuB) and cucurbitacin E (CuE) are tetracyclic triterpene compounds from Cucurbitaceae, and the main bioactive compounds of cucurbitacins tablets that used to treatment of chronic hepatitis. Pharmacological research has been very comprehensive, and there are few studies on pharmacokinetics, especially about CuE. An Ultra High Performance
Zhibin, Wang +8 more
openaire +4 more sources
Phytomedicine, 2023
BACKGROUND The mortality rate of liver cancer ranks third in the world, and hepatocellular carcinoma (HCC) is a malignant tumor of the digestive tract.
Qizhang Li +5 more
semanticscholar +1 more source
BACKGROUND The mortality rate of liver cancer ranks third in the world, and hepatocellular carcinoma (HCC) is a malignant tumor of the digestive tract.
Qizhang Li +5 more
semanticscholar +1 more source
The biosynthesis of cucurbitacin B
Journal of the Chemical Society D: Chemical Communications, 1970Evidence is presented that is consistent with cucurbitacin B being biosynthesized via cycloartenol or parkeol but not through the intermediacy of lanosterol.
J. Malcolm Zander, Donald C. Wigfield
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Phytomedicine, 2023
BACKGROUND Ovarian cancer is a serious threat to women's health, and resistance to chemotherapeutic drugs constitutes one of the principal reasons for ovarian cancer recurrence and the low overall survival rate.
Shuanghong Yin +4 more
semanticscholar +1 more source
BACKGROUND Ovarian cancer is a serious threat to women's health, and resistance to chemotherapeutic drugs constitutes one of the principal reasons for ovarian cancer recurrence and the low overall survival rate.
Shuanghong Yin +4 more
semanticscholar +1 more source
Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Cholestatic liver injury (CLI) is a pathologic process with the impairment of liver and bile secretion and excretion, resulting in an excessive accumulation of bile acids within the liver, which leads to damage to both bile
Shuang-Hua Dai +10 more
semanticscholar +1 more source
ETHNOPHARMACOLOGICAL RELEVANCE Cholestatic liver injury (CLI) is a pathologic process with the impairment of liver and bile secretion and excretion, resulting in an excessive accumulation of bile acids within the liver, which leads to damage to both bile
Shuang-Hua Dai +10 more
semanticscholar +1 more source
Molecular & Cellular Toxicology, 2016
Ethanol is a common risk factor for liver injury. Cucurbitacin B (CuB) is a natural product with potent cytotoxic activities mediated by inducing apoptosis. This study investigated the effect of ethanol on CuB-induced cytotoxicity in LO2 hepatocytes. Low concentration of ethanol alone showed no significant cytotoxic effect on LO2 cells.
Qian Ding +5 more
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Ethanol is a common risk factor for liver injury. Cucurbitacin B (CuB) is a natural product with potent cytotoxic activities mediated by inducing apoptosis. This study investigated the effect of ethanol on CuB-induced cytotoxicity in LO2 hepatocytes. Low concentration of ethanol alone showed no significant cytotoxic effect on LO2 cells.
Qian Ding +5 more
openaire +1 more source
Journal of Medicinal Chemistry, 2023
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity.
Fan Shang +10 more
semanticscholar +1 more source
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity.
Fan Shang +10 more
semanticscholar +1 more source
NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice
Journal of Molecular Endocrinology, 2021Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal-induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with upregulated caspase 1 protease and IL-1β in macrophages.
Ying, Xue +7 more
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Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity
Archives of Biochemistry and Biophysics, 2020Signal transducer and activator of transcription 3 (STAT3) is expressed aberrantly in multiple tumors, including gastric cancer (GC). STAT3 overexpression and excessive activation have been confirmed to play vital roles in tumorigenesis. Cucurbitacin B (CuB) is a natural product with potent anti-cancer activities in solid tumors.
Jiaxin, Xu +12 more
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