Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Lagenaria siceraria (Molina) Standl.] [PDF]
Plants, 2023 Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize +2 more
doaj +2 more sources
Recent Advances in the Application of Cucurbitacins as Anticancer Agents [PDF]
Metabolites, 2023 Cucurbitacins are tetracyclic triterpenoid secondary metabolites, widely distributed in the Cucurbitaceae family. These bitter-tasting compounds act primarily as defense mechanisms against external injuries, and thus against herbivores, and furthermore ...
Bartłomiej Zieniuk +1 more
doaj +2 more sources
Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus [PDF]
Biomolecules, 2023 The vast pool of structurally and functionally distinct secondary metabolites (i.e., natural products (NPs)) is constantly being expanded, a process also driven by the rapid progress in the development of analytical techniques. Such NPs often show potent
Moritz Benka +12 more
doaj +2 more sources
Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends [PDF]
Biomolecules, 2022 Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of ...
Hardeep Singh Tuli +12 more
doaj +2 more sources
Hydroalcoholic Extracts of Cucumis prophetarum L. Affect the Insulin Signaling Pathway in an In Vitro Model of Insulin-Resistant L6 Myotubes [PDF]
MoleculesType 2 diabetes mellitus (T2DM) can be traditionally treated by edible and medicinal species rich in flavonoids and triterpenoids known for their metabolic benefits. Cucumis prophetarum L.
Zewdie Mekonnen +14 more
doaj +2 more sources
Pharmacokinetics and Biological Activity of Cucurbitacins
Pharmaceuticals, 2022 Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions.
Eugenia Elisa Delgado-Tiburcio +6 more
doaj +3 more sources
Pharmacokinetic Profile of Extracts from the Chayote (Sechium edule) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications [PDF]
MoleculesThe hybrid Sechium edule H387 07, commonly known as chayote, has shown potential as an antiproliferative, cytotoxic, and pro-apoptotic agent in the murine leukemia cell lines P388 (macrophagic) and J774 (monocytic) and in the myelomonocytic leukemia cell
Eugenia Elisa Delgado-Tiburcio +6 more
doaj +2 more sources
Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms [PDF]
Journal of Translational Medicine, 2022 Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application.
Carla Varela +6 more
doaj +2 more sources
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities [PDF]
Pharmaceutical Sciences, 2021 For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed ...
Moazzameh Ramezani +3 more
doaj +2 more sources
Squirting Cucumber, Ecballium elaterium (L.) A. Ritch: An Update of Its Chemical and Pharmacological Profile [PDF]
MoleculesEcballium elaterium, also known as squirting cucumber, is a plant which is widespread in temperate regions of Europe, Africa and Asia. The plant is considered to be one of the oldest used drugs. In the last decades, E.
Attilio Anzano +3 more
doaj +2 more sources