Results 171 to 180 of about 2,384 (213)

Antiangiogenic effects of cucurbitacin-I

Archives of Pharmacal Research, 2014
Cucurbitacin-I is a naturally occurring tetracyclic triterpenoid compound with diverse physiological actions that include inducing apoptosis and blocking cell cycle progression of various cancer cells. However, its antiangiogenic activity has not yet been examined.
Hyeon Jin, Kim, Jin-Kyung, Kim
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Cucurbitacins of Colocynthis vulgaris

Phytochemistry, 1988
Abstract The methanolic extract of the fruits of Colocynthis vulgaris on acidic hydrolysis afforded in addition to cucurbitacin I and J a new cucurbitacin designated cucurbitacin T whose structure was elucidated as (24 S )-16,24-anhydro-25-methoxy-2,16α,20β,24-tetrahydroxy-3,11,22-trioxocucurbita-1,5-diene by spectroscopic methods. The biosynthetic
Chandra B. Gamlath, A.A.Leslie Gunatilaka, Khisal A. Alvi, null Atta-ur-Rahman, Sinnathamby Balasubramaniam   +4 more
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The biosynthesis of cucurbitacin B

Journal of the Chemical Society D: Chemical Communications, 1970
Evidence is presented that is consistent with cucurbitacin B being biosynthesized via cycloartenol or parkeol but not through the intermediacy of lanosterol.
J. Malcolm Zander, Donald C. Wigfield
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Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling

Food and Chemical Toxicology, 2014
Cucurbitacin B, a member of the cucurbitaceae family, can act as a STAT3 signaling inhibitor to regulate the growth of hepatocellular carcinoma. STAT3 signaling has been shown to inhibit adipocyte differentiation through C/EBPα and PPARγ. Based on these studies, we hypothesized that cucurbitacin B would prevent PPARγ mediated adipocyte differentiation ...
Cho-Rong, Seo, Dong Kwon, Yang, No-Joon, Song, Ui Jeong, Yun, A-Ryeong, Gwon, Dong-Gyu, Jo, Jae Youl, Cho, Keejung, Yoon, Jee-Yin, Ahn, Chu Won, Nho, Woo Jin, Park, Seung Yul, Yang, Kye Won, Park   +12 more
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Cucurbitacin Contents in Hemsleya dolichocarpa

The American Journal of Chinese Medicine, 1991
Hemsleya dolichocarpa was studied for its cucurbitacin contents during growing period. A colorimetric method was used to determine the total cucurbitacin levels, and a TLC densitometric assay was employed for estimating dihydrocucurbitacin F and its acetate, two active principles in Hemsleya plants. Cucurbitacin contents rise progressively from May to
P Q, Yang, S Y, Liu, Z H, Cao, W J, Chang, C T, Che   +4 more
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Cucurbitacins as Anticancer Agents: A Patent Review

Recent Patents on Anti-Cancer Drug Discovery, 2019
Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its cytotoxic effects.
Hidayat, Hussain, Ivan R, Green, Muhammad, Saleem, Khanzadi F, Khattak, Muhammad, Irshad, Maroof, Ali   +5 more
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Cucurbitacin glycosides from Caput nigri

Phytochemistry, 1995
The chemical structures of cabenosides I-L were investigated. These are four of the 12 cucurbitacin glycosides isolated from 'Cabeça-de-negro', the roots of Caput nigri. By means of chemical analyses the structures of cabenosides I-L were elucidated as 10 alpha-cucurbit-5-ene-3 beta,11 alpha,20S,24 xi,25-pentaol [3, 25-di-O-beta-D-glucopyranoside, and ...
K, Nakano, Y, Kanai, K, Murakami, Y, Takaishi   +3 more
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Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets

Journal of Chromatography B, 2017
Cucurbitacin B (CuB) and cucurbitacin E (CuE) are tetracyclic triterpene compounds from Cucurbitaceae, and the main bioactive compounds of cucurbitacins tablets that used to treatment of chronic hepatitis. Pharmacological research has been very comprehensive, and there are few studies on pharmacokinetics, especially about CuE. An Ultra High Performance
Zhibin, Wang, Wenbo, Zhu, Mingjie, Gao, Chengcui, Wu, Chunjuan, Yang, Jing, Yang, Gaosong, Wu, Bingyou, Yang, Haixue, Kuang   +8 more
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Bioremediation of Cucurbitacins from Cucurbitacin Phytonematicides

2022
Phatu W. Mashela, Ebrahim Shokoohi, Ashwell R. Ndhlala, Kgabo M. Pofu, Dineo Raphasha   +4 more
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The stereochemistry of the cucurbitacins

Tetrahedron Letters, 1960
David Lavie, Youval Shvo, Otto Richard Gottlieb   +2 more
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