Integrated metabolomic and transcriptomic analyses elucidates the molecular mechanisms underlying cucurbitacin accumulation and bitterness development in Luffa fruits [PDF]
BMC Plant BiologyThe fruits of Luffa in the Cucurbitaceae family are characterized by a bitter taste, which is mainly attributed to cucurbitacin. However, the types of cucurbitacins related to bitterness and the molecular mechanism of cucurbitacin accumulation during ...
Dening Zhu +4 more
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Bioassay-guided isolation of leishmanicidal cucurbitacins from Momordica charantia [PDF]
Frontiers in PharmacologyIntroductionLeishmaniasis, a neglected tropical parasitic disease, is regarded as a major public health problem worldwide. The first-line drugs for leishmaniasis suffer from limitations related to toxicity and the development of resistance in certain ...
Maria Carolina Silva Marques +4 more
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Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p [PDF]
Journal of Inflammation ResearchYinyin Zhao,1 Binyuan Jiang,2 Shengnan Zuo3 1Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Medical Research Center of the ...
Zhao Y, Jiang B, Zuo S
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Cucurbitacins and its Anticancer property: A Review [PDF]
Himalayan Journal of Health Sciences, 2019 Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity.
Samuel, Ashmi
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Total cucurbitacins from Herpetospermum pedunculosum pericarp do better than Hu-lu-su-pian (HLSP) in its safety and hepatoprotective efficacy [PDF]
Frontiers in PharmacologyThe pericarp of Herpetospermum pedunculosum (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear.
Wen-Ya Liu +7 more
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Lebensmittelvergiftung durch Cucurbitacine
DMW - Deutsche Medizinische Wochenschrift, 2020 Zusammenfassung Anamnese und klinischer Befund Die 66-jährige Patientin ist wegen einer akuten Lebensmittelvergiftung nach Ingestion von bitteren Zucchini in die Notaufnahme mit Tachykardie, Hypotonie und Somnolenz sowie Exsikkose, Übelkeit, Erbrechen und Hämatochezie eingewiesen worden.
Jung, Carlo +2 more
openaire +3 more sources
The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A.
Naser Jafargholizadeh +2 more
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First Report on the Occurrence of Cucurbitacins in an Italian Melon Landrace (Cucumis melo L.)
Horticulturae, 2023 Scopatizzo, belonging to the Cucumis melo L., is a local variety of Apulia (Southern Italy), which is consumed as unripe melon as an alternative of cucumber due to its better-quality profile and for the absence of cucurbitacins.
Onofrio Davide Palmitessa +8 more
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The effect of squash domestication on a belowground tritrophic interaction
Plant-Environment Interactions, 2022 The domestication of plants has commonly resulted in the loss of plant defense metabolites, with important consequences for the plants' interactions with herbivores and their natural enemies.
Charlyne Jaccard +6 more
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Anti-Cancer Effect of Sesquiterpene and Triterpenoids from Agarwood of Aquilaria sinensis
Molecules, 2022 Two new guaiane sesquiterpenes, aquisinenoids A and B (1 and 2), two new eudesmane-type sesquiterpenoids, aquisinenoids C and D (3 and 4), one new cucurbitacin, aquisinenoid E (5), and five known cucurbitacins (6–10) were isolated from agarwood of ...
Lili Chen +4 more
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