Results 101 to 110 of about 848,063 (302)

Exploring the Potential of Developmental Work Research and Change Laboratory to Support Sustainability Transformations:A Case Study of Organic Agriculture in Zimbabwe [PDF]

, 2018
This paper explores the emergence of transgressive learning in CHAT-informed development work research in a networked organic agriculture case study in Zimbabwe, based on intervention research involving district organic associations tackling ...
McAllister, Georgina, Mudokwani, Kuda, Mukute, Mutizwa, Nyikahadzoi, Kefasi   +3 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Structure and Distortions of the Activity Autoregulation: a Growing Edge of the Cultural-Historical Activity Theory

Культурно-историческая психология
The problem setting of the paper stems from the idea of shifts in research contexts and explanatory emphases in the Cultural-Historical Activity Theory (CHAT) through the history of its development, specifically, from putting the concepts of ...
D.A. Leontiev
doaj   +1 more source

Professional Learning from Disturbances in Healthcare: Managerialism and Compassion [PDF]

International Journal of Management, Knowledge and Learning, 2020
This study asks what behaviours might convert professional disturbances in maternity wards into opportunities for learning within healthcare and how that process is influenced by models of management and leadership.
Katie Willocks, Jem Bendell, Richard Little   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Working with historicity: tracing shifts in contraceptive use in the activity system of sex over time

Psychology in Society, 2012
Sexual activity, sexuality and responses to HIV and AIDS in a rural context in South Africa were studied using a cultural-historical activity theory framework. Activity theory directs the focus onto activity and emphasises the importance of an historical
Mary van der Riet
doaj  

Unknown Vygotsky: Cultural-Historical Theory in the Context of Pavlov’s Theory of Higher Nervous Activity and H. Werner’s Differential Development Theory

Культурно-историческая психология, 2016
The position about the internal connection between the cultural-historical theory of development of higher mental functions of L.S. Vygotsky and two prominent theories of the 20th century is substatianted.
Chuprikova N.I.,
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

First-year students' conflicts during their construction of an academic identity in English as a foreign language: Implementing Cultural-Historical Activity Theory

Bellaterra Journal of Teaching & Learning Language & Literature, 2011
This paper constructs a theoretical framework  that views academic writing from a context-based perspective.   The shift  from text to context results from implementating the  concept of activity system into the academic community, envisioning academia ...
Angels Oliva-Girbau
doaj   +1 more source

The Emotions in Cultural-Historical Activity Theory: Personality, Emotion and Motivation in Social Relations and Activity. [PDF]

Integr Psychol Behav Sci, 2021
Burkitt I.
europepmc   +1 more source