Results 51 to 60 of about 20,808 (258)
Education Policy Analysis Archives, 2015 The English Language Arts Common Core State Standards and corresponding assessments brought about many changes for educators, their literacy instruction, and the literacy learning of their students. This study examined the day-to-day literacy instruction
Jennifer Barrett-Tatum
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Math identity and Cultural Historical Activity Theory:
Outlines. Critical Practice StudiesThe purpose of this exploratory study is to further investigate the cultural contexts under which pre-service teachers develop their mathematics identities. We reviewed pre-service teachers’ mathematics autobiographies that include a description of their math abilities, their perceptions of what it means to be a good student of mathematics and the ...
Socorro Orozco, Aria Razfar
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Cultural Historical Activity Theory, Expansive Learning and Agency in Permaculture Workplaces
Southern African Journal of Environmental Education, 2009 This paper reports on how Cultural Historical Activity Theory was used to identify and analyse contradictions; model and implement solutions in the learning and practice of permaculture at one school and its community in Zimbabwe.
Mutizwa Mukute
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Культурно-историческая психология, 2016 The article represents a brief report on the work of the International Symposium: «Scientific School of L.S. Vygotsky: Traditions and Innovations» and VI th International ISCAR Summer University for PhD Students and young scholars, that were held in ...
Baykovskaya N.A., , Rubtsova O.V.,
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Researcher's Role: An Ethical Dimension
Outlines, 2006 Different paradigms or perspectives function as the point of departure and framework for research. In this article ethical issues in the positivist and constructivist paradigms are presented.
May Britt Postholm, Janne Madsen
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