Results 61 to 70 of about 20,808 (258)
BMC Medical EducationBackground Feedback is an important part of learning, however, it often does not have the desired effect. Much work has been done exploring students’ engagement with feedback and factors which may impact engagement.
Alison Lupton-Smith +2 more
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HUMANIZAÇÃO E ATIVIDADE ESCOLAR NA TEORIA HISTÓRICO-CULTURAL
Cadernos de Pesquisa, 2014 Este artigo tem por objetivo refletir sobre as contribuições da teoria histórico-cultural, particularmente, da teoria da atividade na análise da educação escolar e de seu significado no processo de emancipação dos seres humanos, enfatizando o pensamento ...
Lucinete Marques Lima
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Cultural-Historical Interpretation of Resilience: the implications for practice
Outlines, 2007 Recent attempts at preventing the social exclusion of vulnerable children in England have been driven by notions of resilience which centre primarily on changing children so that they may be better able to cope with adversity.
Anne Edwards, Apostol Apostolov
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Modernity, the Individual, and the Foundations of Cultural–Historical Activity Theory [PDF]
Mind, Culture, and Activity, 2007 It is argued that the problem of individual agency in relation to social institutions can be resolved within Cultural–Historical Activity Theory (CHAT) by the use of the “subject” as a unit of analysis. Such an approach implies a reaffirmation of the fundamental tenets of CHAT but also a critique of the concepts of society and culture, which are ...
openaire +1 more source
Using cultural historical activity theory to reflect on the sociocultural complexities in OSCE examiners' judgements. [PDF]
Adv Health Sci Educ Theory Pract, 2023 Wong WYA +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Frontiers in Education, 2019 The recent scholarship on agency is mostly centered around a relational (also known as situative, contextual, distributed, and ecological) approach that draws attention to agency being situated in context and contingent on sociocultural interactivities ...
Anna Stetsenko
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