Results 101 to 110 of about 16,519 (241)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Religion, Worldview, and Values in an International Class

open access: yesJETEN, 2015
Students attending the international course, “Multicultural Identity in a Global World” (MCI), in Oslo, come from many different European countries, some also from Asia, Africa, Latin-America or the USA.
Geir Hoaas
doaj  

THE EXPRESSION OF COMMUNICATIVE STRATEGIES THROUGH POLITENESS AND CULTURAL CODES IN UZBEK SOCIAL DISCOURSE

open access: yes
This article analyzes the expression of politeness norms and cultural codes in Uzbek social discourse and their role in communicative strategies. The results show that cultural codes and etiquette norms play a crucial role in forming effective persuasive
Baymuradova Laylo Qaxramonovna
core   +1 more source

Hybrid Cultural Codes in Nonwestern Civil Society: Images of Women in Taiwan and Hong Kong

open access: yes, 2010
Scholars have established that cultural codes and styles of expression in civil society must be recognized as informal mechanisms of exclusion, calling into question the possibility of the Habermasian normative ideal of the public sphere.
Yun Fan, Ming-Cheng M. Lo
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Cross-Cultural Research: Methodological Challenges in Translating Meanings and Cultural Codes

open access: yesДискурс профессиональной коммуникации
Researchers in anthropology and psychology conducting cross-cultural comparative studies face a range of complex methodological challenges which significantly impact the validity and reliability of their findings. Paramount among these are issues related
V. N. Burkova   +2 more
doaj   +1 more source

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