Results 81 to 90 of about 16,519 (241)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Kod geopolityczny – koncepcja teoretyczna i metodologiczna

open access: yesPoliteja, 2019
Geopolitical Code – Theoretical and Methodological Concepts The article deals with geopolitical codes in relation to theoretical and methodological assumptions of social and political sciences.
Piotr Lewandowski
doaj   +1 more source

Reading economic magazines: hidden codes and financial crisis representation in Korea

open access: yes, 2017
Previous studies have suggested that media can strongly influence people’s behaviour towards specific events, making use of explicit statements but also hidden codes based mostly on traditional values.
Kim, A.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The role of electronic media in the region in updating cultural codes and forming a complex of identities of the population (the case of Maikop television)

open access: yesВестник Майкопского государственного технологического университета
The issue of preserving cultural codes in ethnic communities in the era of globalization is relevant. The departure of a greater share of social interactions into the digital information space raises the need to include elements of traditional forms of ...
A. M. Siyukhova
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Koncepcja kodów kultury w rosyjskich i ukraińskich badaniach lingwokulturologicznych i etnolingwistycznych

open access: yesAdeptus, 2015
The concept of cultural codes in Russian and Ukrainian linguoculturological and ethnolinguistic studies This article is an attempt at presenting the concept of cultural codes, which was earlier discussed in works of Russian and Ukrainian scholars in ...
Iryna Chybor
doaj   +1 more source

Codes of conduct for Indigenous-inspired spa and wellness tourism

open access: yes, 2015
While the growing global tourism industry currently provides best practices guidance and certification possibilities for ecotourism, green spas, and Indigenous tourism, no codes of conduct exist for spas operations that aim to sustainably integrate ...
Ell, Laura Dawn
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Codes of Commitment to Crime and Resistance: Determining Social and Cultural Factors over the Behaviors of Italian Mafia Women [PDF]

open access: yes, 2014
This article categorizes thirty-three women in four main Italian Mafia groups and explores social and cultural behaviors of these women. This study introduces the feminist theory of belief and action.
Cayli, Baris
core   +1 more source

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