Results 61 to 70 of about 16,519 (241)
Current Swedish Archaeology, 2008 The interior of northern Sweden was thc last area in Europe to become icefree and pioneer settlers arrived soon aftcr deglaciation. Early Mesolithic settlement sites in the Arjeplog area, Sweden, provide evidence of rapid colonization.
Ingela Bergman
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
CULTURAL CODES IN ENGLISH LITERARY WORKS
<p><span>Understanding cultural codes in literary works holds immense significance as it allows readers to decode the layers of meaning hidden beneath the surface of a text. By unraveling these codes, readers can gain insights into the social,
Kholova, Madina
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Codes and Cultural Discourse Analysis
, 2011 The concept of code is used in this body of work to identify a system of beliefs and values that is immanent in communication practices. The concept has its roots in the works of Basil Bernstein, who explored patterns of communication among social ...
Donal Carbaugh
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Creative Components of Film as Social Mechanisms of Meaning Production in Mass Communication
Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Соціологічні дослідження сучасного суспільства: методологія, теорія, методиThe article analyzes the creative components of film as social mechanisms for producing meanings in mass communication. Cinema is considered not only as an art form but also as a media text that encodes and transmits cultural and social meanings through ...
Oleksandra Zinchyna, Yana Kundenko
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