Results 91 to 100 of about 16,519 (241)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Impact of Cultural Differences on the Convergence of International Accounting Codes of Ethics
accounting profession, codes of conduct, codes of ethics, cultural influences, IFAC,
Curtis Clements, John Neill, O. Stovall
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Russian National Branding: Between Cultural Archetypes and Marketing Strategies
RUDN Journal of Studies in Literature and JournalismThe communicative landscape in contemporary Russia demonstrates a marked turn towards national cultural traditions, folklore, and classical art. Unlike the often opportunistic campaigns in popular culture, branding and marketing communications, due to ...
Anton N. Fortunatov +3 more
doaj +1 more source
What is Safe? Cultural Citizenship, Visual Culture and Risk [PDF]
Questions of cultural citizenship and risk have become central to contemporary sociological debates. This paper seeks to relate these concerns to a discussion of ecological citizenship and questions of visual and commercial culture. In the first section,
Nick Stevenson
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
SOSYAL BİR DAVRANIŞBİÇİMİOLARAK DİL
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2007 Etkileşim içindeki bireyler, herhangi bir konuya/olaya ilişkin görüşve düşüncelerini ifade ederlerken, sadece bir konuşma eylemi gerçekleştirmezler, aynızamanda konuyla/olayla ilgili sosyal bir tavır ortaya koyarlar.
Ayhan Selçuk
doaj
Comparing Cultural Clout in Professional Codes of Ethics.
, 2009 Color poster with text and images describing research conducted by Simon A. Wallace and Jonathan P. Burton, advised by Blaine Peden.Whether cultural influence on ethical values is reflected in professional ethics codes of conduct was investigated by ...
Wallace, Simon A., Burton, Jonathan P.
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THEORY OF LINGUOCULTURAL CODES AND UZBEK PROVERBS
, 2021 Culture codes are the key to understanding culture, which allows the identification of cultural information encoded in some form. Cultural codes are also called linguocultural codes. Linguocultural codes are a term of linguocultural studies.
Durdona, Khudayberganova +1 more
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