Results 91 to 100 of about 828,846 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Overcoming cross-cultural group work tensions: mixed student perspectives on the role of social relationships [PDF]

, 2017
As universities worldwide rapidly internationalise, higher education classrooms have become unique spaces for collaboration between students from different countries.
A Schartner, Bart Rienties, CA Bliss, D Gasevic, Denise Whitelock, Dirk Tempelaar, DR Garrison, E Gareis, F Fozdar, J Hommes, J-S Chang, JE Mathieu, Jenna Mittelmeier, K Kimmel, M Lichtman, M Sherry, N Denson, N Harrison, P Levin, P Moore, P Wilcox, S Bahn, VS Singaram, WH Gijselaers, WM Davies, Y Wang, Z Akyol   +26 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Kod geopolityczny – koncepcja teoretyczna i metodologiczna

Politeja, 2019
Geopolitical Code – Theoretical and Methodological Concepts The article deals with geopolitical codes in relation to theoretical and methodological assumptions of social and political sciences.
Piotr Lewandowski
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Морфологічна структура кодів і субкодів у творах О. К. Глушка [PDF]

, 2015
У статті з’ясовано сутність понять «код» та «субкод», визначено їхню роль у семіотичній системі роману «Кінбурн» та збірки оповідань «Маслиновий гай» О. К.
Щербак, О. (O. Shcherbak)
core  

Writing about embodiment as an act of translation [PDF]

, 2016
Writing about embodiment is an act of compression: reducing the sensory complexity of someone else’s physical experience, or even one’s own, into written language that somebody else will understand through sight or sound.
Baker, Catherine
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Koncepcja kodów kultury w rosyjskich i ukraińskich badaniach lingwokulturologicznych i etnolingwistycznych

Adeptus, 2015
The concept of cultural codes in Russian and Ukrainian linguoculturological and ethnolinguistic studies This article is an attempt at presenting the concept of cultural codes, which was earlier discussed in works of Russian and Ukrainian scholars in ...
Iryna Chybor
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source