Results 101 to 110 of about 1,321,495 (304)

Contested identities: exploring the cultural, historical and political complexities of the ‘three Chinas’ [PDF]

open access: yes, 2015
When facing the political, historical and cultural complexities of Mainland China, Hong Kong and Taiwan, problematic issues arise in relation to understanding the sorts of national/cultural identities that might be projected by them.
Jennings, Ros, Li, Qiao
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Bioethics: Reincarnation of Natural Philosophy in Modern Science [PDF]

open access: yes, 2017
The theory of evolution of complex and comprising of human systems and algorithm for its constructing are the synthesis of evolutionary epistemology, philosophical anthropology and concrete scientific empirical basis in ...
Cheshko, Valentin Teodorovich   +2 more
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Teaching knowledge on Historical-Cultural Theory

open access: yes, 2020
O presente artigo busca compreender acerca da Teoria Histórico-Cultural, assim como sua aplicabilidade pedagógica junto aos professores da rede municipal de ensino de uma escola no norte do estado do Paraná. O objetivo consiste em identificar as representações sociais de professoras da rede municipal de ensino sobre a teoria vygotskyana, a fim de ...
Marinho, Amanda Cristina Ferreira   +2 more
openaire   +1 more source

The ethics of suspicion in the study of religions

open access: yes, 2007
In this essay I outline some beliefs and practices among lowland christianised peoples in the Philippines relating primarily to the existence of spirits which are believed to be responsible for causing illness, attending to their imbrication with ...
Tremlett, Paul-Francois
core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

CULTURE UNDER A HISTORICAL-CULTURAL PERSPECTIVE: FIRST APPROACHES

open access: yesTravessias, 2008
This paper derives from a study developed in a Masters Degree lato sensu course focusing the Historical-Cultural Theory, which was offered by the State University of Maring-UEM. It is an investigation, in first approach, regarding the meaning of culture,
Renata Almeida Vieira
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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