Results 71 to 80 of about 1,321,495 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Культурно-историческая психология, 2015 The author reflects on the reasons for the increased interest of modern foreign social cognition researchers in L.S. Vygotsky's cultural-historical theory in the light of the existing methodological contradictions and recent empirical data.
A.B. Kholmogorova
doaj +1 more source
Design smart city apps using activity theory. [PDF]
, 2017 In this paper we describe an innovative approach to the design process of Smart City interventions. We tested it with participants enrolled in the Master\u2019s Degree program in \u201cInnovators in enterprise and public administration\u201d: the ...
Ferranti, C., Petrucco, C.
core +1 more source
Narratives and activity theory as reflective tools in action research [PDF]
, 2012 Narratives and activity theory are useful as socially constructed data collection tools that allow a researcher access to the social, cultural and historical meanings that research participants place on events in their lives.
Stuart, Kaz (Karen)
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Studia Humanitatis, 2019 The article analyses theoretical and methodological foundations of family memory studies in the context of the practical turn and the cultural historical activity theory.
Linchenko Andrei Aleksandrovich
doaj
Cultural-historical theory of psychological phenomena by L. S. Vygotsky
Культурно-историческая психологияThe fate of Lev Semyonovich Vygotsky’s psychological theory is quite extraordinary. The creator of one of the most original theoretical systems in psychology remained unknown to the wider international psychological community until quite
I. Ivic
doaj +1 more source
Historical sociology, international relations and connected histories [PDF]
, 2010 This article addresses three recent developments in historical sociology: (1) neo-Weberian historical sociology within International Relations; (2) the 'civilizational analysis' approach utilized by scholars of 'multiple modernities'; and (3) the 'third ...
Bhambra, Gurminder K.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source