Results 81 to 90 of about 5,658,512 (359)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Puzzles about the “Crowdfunding” in Cultural Industry and Its Ecological Countermeasures

, 2015
With the development of economy and people’s concern about cultural industry, the crowdfunding in cultural industry has welcomed its development opportunity, and many crowdfunding platforms have been developed.
Xiaojing Sun, Q. Meng
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The Impact of Expatriates’ Cross-Cultural Adjustment on Work Stress and Job Involvement in the High-Tech Industry

Frontiers in Psychology, 2019
The personal traits of expatriates influence their work performance in a subsidiary. Nevertheless, organizations tend to hire candidates who are suitable from the technological dimension but ignore personal and family factors.
Min Chen
semanticscholar   +1 more source

Inverse scheduling method for aircraft flat-tail assembly production based on improved genetic algorithm

Scientific Reports
The manufacturing process of the aircraft flat-tail assembly is complex and discrete. It typically involves manual assembly at fixed stations with variable shift teams.
Tengda Li, Min Hua, Junliang Wang, Wei Qin   +3 more
doaj   +1 more source

Real-time sensor networks based on genetic algorithms application in the analysis of innovative data in cultural industry management

Measurement: Sensors
Against the backdrop of sustained economic development and steady improvement of China's overall national strength, the cultural industry is in a good stage of development, but it also faces problems such as data complexity and difficulty in organizing ...
Baohui Zhang, Zaixi Yang, Jinqing Zhang, Qingqing Xu   +3 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A Systematic Review of Contemporary Challenges and Debates on Chinese Food Security: Integrating Priorities, Trade-Offs, and Policy Pathways

Foods
Although food security has been a long-standing focus of research and policy in China, significant gaps remain in synthesizing evolving debates across multiple disciplines such as agriculture, economics, environmental science, and politics.
Rong Zeng, Meseret C. Abate, Baozhong Cai, Amsalu K. Addis, Yonas Derebe Dereso   +4 more
doaj   +1 more source

The Making of the Imaginary Value: Issues in the displacement of image of the Disney production [PDF]

Estudos em Comunicação, 2012
This paper analyzes the problem of displacement of image in the process of creating Disney comics and animation. The research seeks answers to issues of cultural production, especially the representation of the characters and their impact in the minds of
Celbi Vagner Melo Pegoraro
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source