Results 131 to 140 of about 871,084 (301)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Psychological consumption of culinary artistry in the Peak District [PDF]

, 2011
This paper is based upon the culture of culinary artistry, consumption and design. The ranges of sources are specific to The Peak District using Chatsworth House as a case study.
Cseh, Leonard
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Seeing it first-hand: interpreters’ insights from working with LGBTIQA+ individuals settling in Australia

Frontiers in Communication
This article uses the interpreter’s perspective to explore communication challenges arising from linguistic and cultural discordances faced by LGBTIQA+ migrants when accessing public services in Australia.
Miranda Lai, Epperly Zhang, Erika Gonzalez   +2 more
doaj   +1 more source

Culturally Sensitive Learning Practices

IASL Annual Conference Proceedings, 2011
In today’s global world, to provide meaningful education, teacher-librarians and their students need to become culturally competent: open to learning about other cultures and sharing one’s own culture, able to change personal perspectives, and able to communicate effectively across cultures.
openaire   +2 more sources

An Investigation of Successful and Unsuccessful Communication between International and North African Social Workers at Centres for Disabled Children in North Africa [PDF]

, 2011
There is a need to improve the quality of life for disabled children in North Africa. Although local governments and communities have been providing social services support, an increase in social services investment, particularly, specialists who work in
Okuyama, Yusuke
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessment through a cross-cultural lens in North American higher education

Frontiers in Education, 2022
Sara Mortaz Hejri, Rodica Ivan, Nimo Jama   +2 more
doaj   +1 more source

Polyphonic bricolage and cultural humility: A framework for reimagining art therapy practice in the Afro-Caribbean context

South African Journal of Arts Therapies
This article proposes polyphonic bricolage, a concept introduced by Schmidt (2006), that embraces the dynamic blending of diverse cultural influences as a tool for addressing the psychosocial needs of Afro-Caribbean clients in art therapy.
Kim Valldejuli
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source