Results 131 to 140 of about 188,093 (303)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Nursing in a multicultural world: Cultural competence and sensitivity as ethical imperatives

open access: yesAnnals of Tropical Research
Healthcare today is marked by growing cultural diversity, which profoundly shapes the way nurses deliver care. This perspective article argues that cultural competence and cultural sensitivity are not optional skills but essential dimensions of effective
France Allan Cavite
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Culturally Sensitive Learning Practices

open access: yesIASL Annual Conference Proceedings, 2011
In today’s global world, to provide meaningful education, teacher-librarians and their students need to become culturally competent: open to learning about other cultures and sharing one’s own culture, able to change personal perspectives, and able to communicate effectively across cultures.
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Seeing it first-hand: interpreters’ insights from working with LGBTIQA+ individuals settling in Australia

open access: yesFrontiers in Communication
This article uses the interpreter’s perspective to explore communication challenges arising from linguistic and cultural discordances faced by LGBTIQA+ migrants when accessing public services in Australia.
Miranda Lai   +2 more
doaj   +1 more source

Cultural Safety: A Framework for Changing Attitudes

open access: yes, 1993
When nursing first recognised cultural difference as an issue for nursing practice, it framed it in terms of achieving sensitivity to the needs of people of different cultures.  A significant shift came in 1988.
Margaret Schwass, Pamela Wood
core  

Cultural Sensitivity in Nursing: Making a World Out of Difference [PDF]

open access: yes, 1997
This thesis examines the meanings that nurses attach to the concept of “cultural sensitivity”. The findings are drawn from an extensive review of nursing's formal discourse (the nursing literature) and nurses' informal discourse (indepth interviews with ...
Cerny, Lesley
core  

Cross-cultural sensitivity in forensic mental health care

open access: yes, 2021
Cross-cultural sensitivity in forensic mental health ...
S Shepherd (13598530)   +2 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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