Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Health Social Workers in Promoting Mental Health Equity: Voice and Agency for the Marginalized
Globally, 1 in 4 persons have mental health issues at some point in life. However, the mental health services are not easily available, accessible and affordable to all strata of the society with varying socio-economic and cultural backgrounds.
Chandramathi Ramaswamy +4 more
doaj
Bridging cultural sensitivity and ethical practice: Expert narratives on child and adolescent mental health in Kuwait. [PDF]
Chebli K, Gritti A, Calia C.
europepmc +1 more source
An Opportunity to Integrate Cultural Sensitivity Training Into the Doctor of Pharmacy Curriculum. [PDF]
Haas-Gehres A +3 more
europepmc +1 more source
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Enhancing cultural sensitivity in medical education: a central pillar for patient-centered care. [PDF]
Jiang Y, Samah NA.
europepmc +1 more source
Cultural Competence and Cultural Sensitivity Education in University Nursing Courses. A Scoping Review. [PDF]
Gradellini C +5 more
europepmc +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Reconciliation in health care must go beyond cultural sensitivity. [PDF]
Duong D.
europepmc +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source

