Results 81 to 90 of about 856,844 (349)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Speech and language therapists’ perceptions of corporate practice in South Africa

South African Journal of Communication Disorders
Background: Corporate speech and language therapy (CSALT) is an emerging field that extends the role of speech and language therapists (SALTs) into corporate environments, enhancing workplace communication and interpersonal skills.
Ntandoyenkosi L. Msomi, Suvishka Barath, Andrew J. Ross   +2 more
doaj   +1 more source

From Cousin Joe to the Comoros: Orthography and the Politics of Choice in Africa and African America [PDF]

, 2003
This paper explores issues of orthographic representation in two different projects, in two different locations, and draws some general conclusions about the role of an outsider linguistic anthropologist in working with individuals and their data.
Ottenheimer, Harriet Joseph
core   +1 more source

Sociolinguistic Conditioning of Phonetic Category Realisation in Non-Native Speech [PDF]

, 2009
The realisation of phonetic categories reflects a complex relationship between individual phonetic parameters and both linguistic and extra-linguistic conditioning of language usage.
Waniek-Klimczak, Ewa
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cultural sensitivity and sports: a case study of college students

Physical Education of Students
Background and Study Aim. Sports participation plays a significant role in promoting physical and mental well-being. However, in many conservative societies, cultural sensitivity greatly impacts women's engagement in physical activities.
Sm Farooque, Sobena Begum, Ahsan Huda Yumkhaibam, Sanjib Kumar Bhowmik   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Supporting continuing bonds for parents with infants with uncertain futures on neonatal units in the United Kingdom: co-designing a culturally sensitive music therapy intervention

Frontiers in Psychiatry
IntroductionNeonatal intensive care is a traumatic environment for parents, infants and staff. Services need to collaborate with their users to develop acceptable and sustainable support.
Kirsty Jane, Ruby Hayns-Worthington, Katie Gallagher, Polly Livermore, Helen Shoemark, Glenn Robert   +5 more
doaj   +1 more source

Cultural respect encompassing simulation training: being heard about health through broadband [PDF]

, 2016
Background. Cultural Respect Encompassing Simulation Training (CREST) is a learning program that uses simulation to provide health professional students and practitioners with strategies to communicate sensitively with culturally and linguistically ...
Elliott, K, Livesay, Karen, Min-Yu Lau, P, Nicholson, P, Woodward-Kron, R   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source