Results 51 to 60 of about 3,295,981 (286)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

ДО ІСТОРІЇ МІСЬКОГО СВЯТА (УКРАЇНСЬКО-НІМЕЦЬКІ ПАРАЛЕЛІ) / To the History of Urban Holidays (Ukrainian-German Parallels)

Актуальні питання суспільних наук та історії медицини, 2015
Курочкин Олександр. К истории городского праздника (украинско-немецкие параллели). Долгое время украинская народоведческая наука занималась преимущественно изучением культуры и быта сельского населения.
Курочкін Олександр
doaj  

Reflections on Traditional Chinese Medicine's Modernization

Yixue yu zhexue
The concept of cultural tradition emphasizes the intrinsic cultural genes of tradition, while traditional culture focuses more on the socio-cultural conditions of the present, highlighting the temporal and contextual presence of culture.
Weihua PENG
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Reinvention of Tradition in Making and Exhibiting of Dowry in Anatolian Culture [PDF]

Pad, 2021
Marriage is a significant part of almost every culture. As a cultural phenomenon, marriage consists of traditional patterns that connect material and spiritual culture and give it belonging to a culture.
Aybeniz Gökmen, Fatma Nur Gökdeniz Zeynali   +1 more
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Understanding Cultural Persistence and Change

The Review of Economic Studies, 2017
We examine a determinant of cultural persistence that has emerged from a class of models in evolutionary anthropology: the similarity of the environment across generations.
Paola Giuliano, Nathan Nunn
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

TRANSLATION OF OSCAR WILDE TALESAND THEIR ADAPTATION PROBLEMS TO ANOTHER CULTURE

Polylinguality and Transcultural Practices, 2015
Oscar Wilde’s idea in his fairy tale was to make them such as he was himself - an outstanding and extremely deep - an outline traced in all his tales. Each word in a fairy tale is a symbol. It was his way of writing that makes translator job complicated.
V N Zimyanina
doaj