Results 61 to 70 of about 2,133,258 (309)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Trabalho digno expressando valores universais e respeitando diversidade cultural: Proposições para a intervenção

Psychologica, 2019
Decent work is a comprehensive concept expressing people’s aspirations for their working lives. This concept has had great legitimacy since it was proposed by the International Labour Organization, the United Nations agency for labour issues, which is ...
Nuno Rebelo dos Santos
doaj   +1 more source

Sensitive electrochemiluminescence (ECL) immunoassays for detecting lipoarabinomannan (LAM) and ESAT-6 in urine and serum from tuberculosis patients. [PDF]

, 2019
BackgroundTuberculosis (TB) infection was responsible for an estimated 1.3 million deaths in 2017. Better diagnostic tools are urgently needed. We sought to determine whether accurate TB antigen detection in blood or urine has the potential to meet the ...
Barbero, Simone, Bartlett, Daniel, Broger, Tobias, Denkinger, Claudia M, Katsuragi, Kiyonori, Kawasaki, Masanori, Lowary, Todd L, Mathew, Anu, Moreau, Emmanuel, Nahid, Payam, Pinter, Abraham, Plisova, Tatiana, Sigal, George B, Tsionksy, Michael   +13 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Barriers to Recruiting an Adequate Sample in Rural Nursing Research

Online Journal of Rural Nursing and Health Care, 2004
Recruiting an adequate sample in rural nursing research has its unique challenges. In this article, nurse researchers share their adventures in recruiting study participants from four studies in the rural West.
Shirley Cudney, Carol Craig, Elizabeth Nichols, Clarann Weinert   +3 more
doaj   +1 more source

BACTERIOLOGICAL PROFILE OF WOUND INFECTION AND ANTIBIOTIC SUSCEPTIBILITY PATTERNS IN A PUBLIC HOSPITAL IN SURABAYA, INDONESIA

Journal of Vocational Health Studies, 2023
Background: Pyogenic infections that occur can be caused by direct bacterial contamination of the wound, such as infection in a post-surgical wound or infection after trauma. Efforts to control infection can be done with the use of antibiotics.
Ika Ayunur Kholifah, Dwi Wahyu Indriati, Ratna Wahyuni, Aliyah Siti Sundari   +3 more
doaj   +1 more source

Culturally sensitive mental health research: a scoping review

BMC Psychiatry
Abstract Background Given disparities in healthcare outcomes between ethnocultural groups, there is a need for research to be sensitive to cultural needs and differences to consequently address health inequalities. As part of a project aiming to co-produce a publicly acceptable core mental health dataset (CMHDS) for ...
Phoebe Lyons, Auden Edwardes, Laura Bladon, Kathryn M. Abel   +3 more
openaire   +3 more sources

Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells. [PDF]

, 2017
Precision cancer medicine seeks to target the underlying genetic alterations of cancer; however, it has been challenging to use genetic profiles of individual patients in identifying the most appropriate anti-cancer drugs. This spurred the development of
Dall'Era, Marc A, de Vere White, Ralph W, Gheibi, Pantea, Ma, Ai-Hong, Pan, Chong-Xian, Revzin, Alexander, Son, Kyung Jin, Vu, Tam, Yap, Stanley Alexander, Zeng, Shuxiong   +9 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Detecting the Aspergillus spp. In(BAL) Fluid Samples by Nested PCR, Culture and Direct Smear

پیاورد سلامت, 2011
Background and Aim: Aspergillosis are the most prevalent cause of the respiratory infections. These fungi show invasive aspergillosis(IA) in immunocompromised patients.
Seyed Amir Yazdanparast, Ghazaleh Ghandchi, Fariba Heshmati, Sanam Afshar Moghaddam, Mohammad Ali Khodadoust   +4 more
doaj