Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Occupational Safety and Health (OSH) management systems: towards development of safety and health culture [PDF]
, 2006 The unsatisfactory OSH record of the construction industry has always been highlighted. It is because the OSH management system is a neglected area and a function that has not been pursued systematically in the construction industry.
Bakri, Ahmadon +3 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Discover SustainabilitySpatial ability is an important skill for art students, and its learning difficulty lies in the students' need to form abstract three-dimensional thinking and spatial perception.
Yi Jian, Juliana Aida Abu Bakar
doaj +1 more source
A indústria cultural brasileira na formulação de Renato Ortiz
Ciências Sociais Unisinos, 2018 The article focuses on Renato Ortiz’s interpretation of the culture industry in Brazil. The hypothesis proposed by him became a reference for other authors and a part of a common consolidated knowledge, which does not always recognize its origin in the ...
Marcelo Ridenti
doaj +1 more source
Determining the factor structure of an integrated innovation model [PDF]
, 2009 This paper reports on elemental factor analyses of the innovativeness study in the Turkish manufacturing industry, drawing on a sample of 184 manufacturing firms.
Alpkan, Lutfihak +7 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Development of Wushu culture industry using internet of things technology: A case study of Anhui Province, China. [PDF]
Heliyon, 2023 Wang S, Chen Y, Liang D, Zhang L.
europepmc +1 more source
National culture and risk-taking: Evidence from the insurance industry
Journal of business research, 2019 The gravity of insurance within the financial sector is constantly increasing. Reasonably, after the events of the recent financial turmoil, the domain of research that examines the factors driving the risk-taking of this industry has been signified. The
Chrysovalantis Gaganis +3 more
semanticscholar +1 more source
The impact of the prevailing organizational culture on the adoption of green marketing in chemical-industry companies in three Arab states in west Asia [PDF]
The objective of this study was to investigate the impact of the prevailing organizational culture on the adoption of green marketing in chemical-industry companies in three countries: Syria, Kuwait and Jordan. The research used a survey methodology.
Nahla Al-Rifai, Tareq N. Hashem
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