Results 91 to 100 of about 8,418,026 (404)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Video game preservation in the UK: a survey of records management practices [PDF]

open access: yes, 2014
Video games are a cultural phenomenon; a medium like no other that has become one of the largest entertainment sectors in the world. While the UK boasts an enviable games development heritage, it risks losing a major part of its cultural output through ...
Bachell, Alasdair, Barr, Matthew
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Reflections on Bolaño’s Culture Industry

open access: yestripleC: Communication, Capitalism & Critique, 2015
Bolaño’s study of the culture industry builds on Adorno and Horkheimer’s “The Culture Industry: Enlightenment as Mass Deception” linking it to Habermas’ and Enzensberger’s work.
Thomas Klikauer
doaj   +1 more source

The impact of the prevailing organizational culture on the adoption of green marketing in chemical-industry companies in three Arab states in west Asia [PDF]

open access: yes
The objective of this study was to investigate the impact of the prevailing organizational culture on the adoption of green marketing in chemical-industry companies in three countries: Syria, Kuwait and Jordan. The research used a survey methodology.
Nahla Al-Rifai, Tareq N. Hashem
core  

Quality Culture of Manufacturing Enterprises: A Possible Way to Adaptation to Industry 4.0

open access: yesThe social science, 2019
The concept of Industry 4.0 means a new paradigm of modern manufacturing. This phenomenon requires continuous innovation processes and technological development from each enterprise.
Pavol Durana   +4 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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