Results 71 to 80 of about 1,813,775 (308)

New Zealand culture of intoxication: Local and global influences [PDF]

open access: yes, 2010
This article shows that attitudes towards and behaviours involving the consumption of alcohol in New Zealand have long been problematic. It provides an historical account of social, economic and legislative factors which have influenced the development ...
Campbell, Maxine M.   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Quasi-firms for real innovations [PDF]

open access: yes, 1997
The construction industry is notorious for its (lack of) innovativeness. Many papers, reports\ud and articles have been written on this subject already for more than three decades.\ud The explanations presented can be summarized by such terms as ...
Dorée, A.G., Tongeren, H. van
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Willamette Valley Epilogue [PDF]

open access: yes, 2014
Rusty Gaffney gives a brief overview of the culture of the wine industry in Oregon, focusing on the wineries of the Willamette Valley, in this article from his Prince of Pinot blog, volume 9, issue 42.
Gaffney, William Rusty
core   +1 more source

Sunderland Software City: The Impact of a Collaborative Project to Develop the Software Industry within the North East of England [PDF]

open access: yes
This paper uses a case study approach to evaluate the impact of a collaborative initiative within the North East of England which sets out to grow and sustain a software industry, based on the strengths of regional players.
Dunn, D   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Structural model of celebrityization and daily life of social network users (case study of Tehrani users of Instagram social network) [PDF]

open access: yesمطالعات رسانه‌های نوین
Today, the media world and its audiences are experiencing a paradigm shift from an era that was characterized by a one-sided, ideology-driven media industry that favored a one-sided, monologue, and dictatorial approach. In contrast, the digital world and
Azam Velayati   +2 more
doaj   +1 more source

GORONTALO’S ARTS AND CULTURAL POTENTIALS AND LOG WASTE AS MEANS OF WORK OF ARTS IN SUPPORTING CREATIVE INDUSTRIES [PDF]

open access: yes, 2010
This article is based on research result that was financed by DP2M DIKTI on 2009 budgeting year with contract number 123/H47.C1/PL/2009.the research aimed to desain a craft souvenir by utilizing the potential of culture and art of Gorontalo as source of
Has, Diana, I Wayan, Sudana
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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