Results 71 to 80 of about 311,135 (313)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The Impact of the Integration of the Culture Industry and Tourism on Regional Green Development: Empirical Evidence from China [PDF]
The concept of “green development” has garnered increasing recognition and prominence in recent years, attracting the attention of various countries and regions. How to achieve green development has become a pressing issue for the government.
Zhenyu Qi, Yuezhou You
core +1 more source
EludamosTraditionally, theories of play and games have drawn a clear distinction between two different forms of activity; play and labour. Over the last two decades, the concept of playbour has challenged this division, with empirical studies and observations ...
Tuomas Manninen
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Organizational culture, leadership style and effectiveness: A case study of middle eastern construction clients [PDF]
, 2013 During the last few decades, organizational effectiveness has received a great deal of attention in many industrial sectors. As a result, a variety of models have been formulated which measure organizational performance. In the construction industry, two
Alnasseri, Nasser +2 more
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Exporting Chinese culture: industry financing models in film and television [PDF]
, 2006 This article examines the financing of creative industries in the People’s Republic of China. Creative industries embrace both traditional and contemporary culture, but exportable industries are primarily content-driven.
Keane, Michael A., Michael Keane
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An Action Research of Seediq Culture from Knowledge Management [PDF]
, 2009 [[abstract]]Seediq mei-hsi tribe in Nantou comes within the scope of this study. First, this study finds the information of knowledge management and local culture industry, and interviews the leaders of tribe organization.
Wang, Chia-Shiun
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source