Results 61 to 70 of about 6,653,826 (260)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Reflections on Bolaño’s Culture Industry
tripleC: Communication, Capitalism & Critique, 2015 Bolaño’s study of the culture industry builds on Adorno and Horkheimer’s “The Culture Industry: Enlightenment as Mass Deception” linking it to Habermas’ and Enzensberger’s work.
Thomas Klikauer
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
H-ermes: Journal of Communication, 2013 The essay by Adorno and Horkheimer about The Culture Industry (in the volume Dialectic of Enlightment) represents for Alberto Abruzzese the starting point of a reasoning on the intellectuals' role, the crisis of humanistic and academic knowledge and the ...
Alberto Abruzzese
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
EludamosTraditionally, theories of play and games have drawn a clear distinction between two different forms of activity; play and labour. Over the last two decades, the concept of playbour has challenged this division, with empirical studies and observations ...
Tuomas Manninen
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Culture Industry and Participatory Audiences
, 2017 This project offers a new critique of participatory media practices. While the concept of participatory culture is often theorised as embodying the possibility of a potentially utopian future of media engagement and participation, this book argues that ...
Keltie, Emma (R17735)
core +1 more source