Results 51 to 60 of about 1,813,775 (308)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Sınırların Metalaştırılması ve Bir Kültür Endüstrisi Örneği Olarak E-Mülteci Oyunu
Tiyatro Eleştirmenliği ve Dramaturji Bölümü DergisiSedef Ecer’in E-Mülteci adlı oyunu göç ve mültecilik kavramlarını sosyal medya ve sosyal medyanın bireyler üzerindeki gücü üzerinden irdeler. Oyun iltica etmek zorunda kalan üç kadının trajedisini Adorno ve Horkheimer’ın tanımladıkları kültür endüstrisi ...
Banu Öğünç
doaj +1 more source
Marine shrimp culture industry of Thailand: operating guidelines for shrimp farms. [PDF]
, 2005 The marine shrimp industry in Thailand had developed a code of conduct for its operations. This code of conduct is a set of principles and processes that provides a framework to meet the industry’s goal for environmental, social, and economic ...
Boyd, Claude E. +4 more
core +1 more source
Organizational culture, leadership style and effectiveness: A case study of middle eastern construction clients [PDF]
, 2013 During the last few decades, organizational effectiveness has received a great deal of attention in many industrial sectors. As a result, a variety of models have been formulated which measure organizational performance. In the construction industry, two
Adams, Jens +12 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Eleştirel Teori Perspektifinden Barbie Filminin Betimsel Analizi
Türkiye Film Araştırmaları DergisiBu araştırmada kültür endüstrisinin en önemli araçlarından biri olan sinemanın üretmiş olduğu metalar ele alınmaktadır. Çalışmanın amacı tüketim toplumunu problem alarak, kitlelerin kültürel ürünler aracılığıyla hegemonya altına alınabildiğini ...
Feyza Karaboğa, Yusuf Adıgüzel
doaj +1 more source
Drivers of organizational creativity [PDF]
, 2005 A path model of organizational creativity was presented; it conceptualized the influences of information sharing, learning culture, motivation, and networking on creative climate.
Dimenäs, Elof +3 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Acta AcademicaThis article investigates the intersection between critical theory and hermeneutics, examining whether Hans-Georg Gadamer’s aesthetic philosophy – especially his critique of Kantian aesthetics – might offer an ontological alternative to the culture ...
William Shaer
doaj +1 more source