Results 201 to 210 of about 437,976 (307)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Protocol for insulin dosing during expansion and maturation of human iPSC-derived cardiomyocytes. [PDF]

STAR Protoc
Verbueken D, Yuan Q, Warnaar VAJ, Ayubi S, Zhang K, Kemna LJM, Bertrand L, Chamuleau SAJ, van der Velden J, Buikema JW.   +9 more
europepmc   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

A small molecule strategy with forskolin and p38 inhibitor for serum-free muscle stem cell expansion. [PDF]

NPJ Sci Food
Lu H, Liu Z, Liu X, Pan Y, Yan D, Cheng X, Zhang L, Ding S, Li C, Zhou G, Guo R.   +10 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Revisiting ISO 10993-5 In Vitro Cytotoxicity Standard Tests for Evaluation of Extracellular Matrix-Based Biomaterials. [PDF]

Int J Biomater
Ramakrishnan R, Daly AC.
europepmc   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Feeder-free generation of functional dendritic cells from human pluripotent stem cells. [PDF]

J Immunother Cancer
Jung WH, Khalil A, Binenbaum Y, Price JM, Vining KH, Lungjangwa T, Sobral MC, Jaenisch R, Mooney DJ.   +8 more
europepmc   +1 more source

High‐Throughput Digital Decoding of Vascular Heterogeneity in Patient‐Specific Tumor Microenvironments

Advanced Healthcare Materials, EarlyView.
ABSTRACT Quantitative characterization of vascular heterogeneity in complex microphysiological systems (MPS), particularly within patient‐derived tumor microenvironments, remains a major challenge for scalable disease modeling and therapeutic evaluation.
Jungseub Lee, Wooju Park, Sujin Hyung, Sangmin Jung, Kyungho Lee, Junseok Jeon, Noo Li Jeon, Jeeyun Lee, Hye Ryoun Jang, Jihoon Ko   +9 more
wiley   +1 more source

Serum-free production of anti-huCD20(hγ1)-IL2no-alpha immunocytokine: a promising therapeutic for B-NHL. [PDF]

Front Bioeng Biotechnol
Bergantiños Albernas DL, Azahares Valdivia E, Pérez Rosales CL, Hurtado de Mendoza Arrieta AL, Castellanos Díaz CLM, González MÁ, Sosa Aguiar K, Gómez Peña T, Santo Tomás Pompa JF, Palacios-Oliva J, Rashida De la Luz Hernández K, Hernández T, Casadesús Pazos AV.   +12 more
europepmc   +1 more source