Results 81 to 90 of about 6,992,473 (362)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

We Live Here, and We Are Queer!: Young Gay Connected Migrants’ Transnational Ties and Integration in the Netherlands

Media and Communication, 2019
Upon arrival to Europe, young migrants are found grappling with new language demands, cultural expectations, values, and beliefs that may differ from global youth culture and their country of origin.
Jeffrey Patterson, Koen Leurs
doaj   +1 more source

Cultural Expertise and the Media

, 2023
Rozdział dotyczy kompetencji medialnych jako specyficznego rodzaju wiedzy kulturowej, wymagającej starannego badania i samoświadomego używania w kontekście prawnym. Czytelnik rozdziału zapozna się z problemami związanymi z treściami mediów niezgodnymi z regułami społecznymi lub potencjalnie niebezpiecznymi; o roli nieustannie ewoluujących narzędzi ...
openaire   +2 more sources

Cytotoxic effects of nanosilver are highly dependent on the chloride concentration and the presence of organic compounds in the cell culture media

Journal of Nanobiotechnology, 2017
BackgroundNanosilver shows great promise for use in industrial, consumer or medical products because of its antimicrobial properties. However, the underlying mechanisms of the effects of silver nanoparticles on human cells are still controversial ...
J. Kaiser, M. Roesslein, L. Diener, A. Wichser, B. Nowack, P. Wick   +5 more
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

The Evolution of Government Intervention in the Mediterranean Media System: Spain, France, and Portugal

Media and Communication
Based on the comparative analysis of the three Western media system models distinguished by Daniel Hallin and Paolo Mancini (2004), this article revisits their thesis of a tendency towards the convergence of the Mediterranean model and the Liberal model ...
Ana Fernández-Viso, Isabel Fernández-Alonso   +1 more
doaj   +1 more source

The prevalence of victimization and the internet abuse in student population [PDF]

Temida, 2016
The use of modern information technology has contributed to the creation of new media and virtual tools that contribute to mass social interaction.
Baltezarević Vesna, Baltezarević Radoslav, Baltezarević Borivoje   +2 more
doaj   +1 more source

Ammonium accumulation in commercially available embryo culture media and protein supplements during storage at 2-8°C and during incubation at 37°C.

Human Reproduction, 2016
STUDY QUESTION Does ammonium accumulate in commercially available culture media and protein supplements used for in vitro development of human pre-implantation embryos during storage and incubation?
Sander H. M. Kleijkers, A. V. van Montfoort, O. Bekers, E. Coonen, J. Derhaag, J. Evers, J. Dumoulin   +6 more
semanticscholar   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source