Results 111 to 120 of about 15,620,197 (326)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Human embryos cultured in vitro to 14 days [PDF]
, 2017 We know a great deal about the development of the mammalian embryo until the time that the blastocyst implants into the uterus. With model organisms such as the mouse, we have also developed a considerable understanding of development immediately around ...
Morris, Samantha A.
core +2 more sources
Journal of Extracellular Vesicles, 2016 Extracellular vesicles (EVs) represent an important mode of intercellular communication. Research in this field has grown rapidly in the last few years, and there is a plethora of techniques for the isolation and characterization of EVs, many of which ...
C. Gardiner +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Why is the World Short of Democracy? A Cross-Country Ananlysis of Barriers to Representative Government [PDF]
This study first uses a set of graphs and tables to present the pattern of democracy in the world, using the Gastil Index. Then a statistical analysis is conducted by two techniques: Regression techniques are used to analyze the effect on democracy of a ...
Martin Paldam, Vani K. Borooah
core
Physical Activity and HealthBackground: There is currently no study that concurrently investigates physical activity, sedentary lifestyle, pulmonary function, HIT-6 Score, and the impact of smoking in young adults.
Asuman Saltan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Sustainability of direct seeding versus conventional tillage [PDF]
, 2006 Pour analyser la durabilité du semis direct sur mulch (SDM) dans les conditions méditerranéennes, une comparaison culture traditionnelle (CT) et SDM a été réalisée sur un site expérimental à Montpellier, dans le sud de la France depuis 2000. Un blé dur a
Khaledian, Mohammadreza +3 more
core
Micropropagation for the production of high quality phytochemicals [PDF]
, 2013 Plants area source of many valuable secondary metabolites that find a broad field of applications, ranging from the agrochemical to the pharmaceutical industries.
Grevenstuk, Tomás, Romano, Anabela
core +1 more source
Techniques of DNA-studies on prehispanic ectoparasites (Pulex sp., Pulicidae, Siphonaptera) from animal mummies of the Chiribaya Culture, Southern Peru [PDF]
, 2003 Katharina Dittmar +5 more
openalex +1 more source