Results 241 to 250 of about 3,744,569 (304)

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Metabolic interactions and growth dynamics of <i>Bifidobacterium</i> strains in response to human milk oligosaccharides and lactose. [PDF]

Front Microbiol
Ratering S, Schnell S, Borsch C, Morrin ST, Hill DR, Buck RH, Rudloff S.   +6 more
europepmc   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Antiviral Activity and Mucosal Safety of Novel Human-Milk-Inspired Antimicrobial Peptides. [PDF]

Pharmaceutics
Yousefieh N, Ouattara LA, Bhutta M, Shah IM, Herrera C, Doncel GF.   +5 more
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Water buffalo milk: physicochemical, nutritional properties, and potential benefits for human health. [PDF]

Front Nutr
Mota-Rojas D, Napolitano F, Fernandes Bettencourt A, Bragaglio A, Nannoni E, Lanzoni L, Chay-Canul A, Álvarez-Macías A, Domínguez-Oliva A, Fischer V, Abd El-Aziz AH, Martínez-Burnes J, Hernández-Avalos I, Mora-Medina P, Olmos-Hernández A, Torres-Bernal F, Jose N, Braghieri A.   +17 more
europepmc   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Human Milk Oligosaccharides in Sports Nutrition: Biological Rationale and Current Evidence. [PDF]

Nutrients
Hu K, Zhang K, Huang C, Wang Z, Huang X, Li Y, Cheng L, Wu Y.   +7 more
europepmc   +1 more source

Culturing Goat Milk: Estonian Goat Milk Farming and Artisanal Made Products

, 2020
openaire   +1 more source

Recombinant Expression and Functional Analysis of GH2 β-Galactosidases Derived from <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> NSP1 and <i>Streptococcus thermophilus</i> RB16. [PDF]

Int J Mol Sci
Shamsiyeva Y, Kostanova A, Tursunbekova A, Khassenov B, Akishev Z.   +4 more
europepmc   +1 more source