Results 81 to 90 of about 217,978 (314)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

open access: yesAdvanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv   +10 more
wiley   +1 more source

Prevalence of enterotoxigenic Staphylococcus aureus in organic milk and cheese in Tabriz, Iran

open access: yesIranian Journal of Microbiology, 2014
Background and Objectives: Staphylococcal food poisoning is a gastrointestinal disease, which is caused by consumption of contaminated food with enterotoxins produced by Staphylococcus aureus (SEs).
Yalda Rahbar-Saadat   +4 more
doaj  

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo   +7 more
wiley   +1 more source

Isolation and identification of Salmonella typhimurium from raw cow, sheep and goat milk in Chahamaha Va Bakhteyari Province [PDF]

open access: yesBihdāsht-i Mavādd-i Ghaz̠āyī, 2014
Salmonella typhimurium and S. enteritidisare known as the major causes of food-borne infection throughout the world. The present study was carried out to investigate the prevalence of S. typhimurium in raw milks of Chahamaha Va Bakhteyari province.
F Tajbakhsh, E Rahimi, E Tajbakhsh
doaj  

Influence of Dissolved Oxygen on Acid Production in Buffalo Milk by Lactic Cultures

open access: yesJournal of Food Protection, 1983
Rates of acid production in buffalo milk by lactic cultures increased with the decrease of oxygen content to 2.90 ppm. Rates of production in milk samples containing less than 2.90 ppm dissolved oxygen did not vary. Incorporating oxygen into milk to raise the initial oxygen content from 5.50 to 9.00 ppm strongly inhibited acid production by all lactic ...
S, Shekar, G S, Bhat
openaire   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

open access: yesAdvanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu   +14 more
wiley   +1 more source

MICROBIAL QUALITY OF MILK AVAILABLE IN KATHMANDU VALLEY

open access: yesJournal of Nepal Medical Association, 2004
With an objective to find microbial quality of the market milk available in Kathmandu valley, this study was conducted in the Microbiology Laboratory, Himalayan College of Agriculture Science and Technology (HICAST).
Charu Arjyal, B N Dahal, B Khadka
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao   +8 more
wiley   +1 more source

SOMATIC CELL COUNT VARIATION IN MILK FROM SHEEP WITH SUBCLINICAL MASTITIS

open access: yesВетеринарная патология, 2014
There are considerable gaps in diagnostics of mastitis in sheep as compared with other agricultural animals. Sheep milk has large economical importance, especially in the regions where the sheep are milked.
G. N. Urazmetova, A. Y. Aliev
doaj  

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